Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China and Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
Chem Commun (Camb). 2020 May 21;56(41):5512-5515. doi: 10.1039/d0cc01800g.
We developed a host-guest ATP responsive strategy for efficient intracellular delivery of phosphopeptides, employing a pegylated arginine clustered calix[5]arene nanocarrier system that has great capability of recognizing the phosphate moieties on peptides and penetrating the cell membrane.
我们开发了一种主体-客体 ATP 响应策略，用于高效地在细胞内递送磷酸肽，采用了一种聚乙二醇化的精氨酸聚集的杯[5]芳烃纳米载体系统，该系统具有识别肽上的磷酸部分和穿透细胞膜的强大能力。
