CCVC, PROTEO, Département de chimie , Université Laval , 1045 Avenue de la Médecine , Québec , Québec, G1V 0A6 , Canada.
Org Lett. 2019 Dec 6;21(23):9759-9762. doi: 10.1021/acs.orglett.9b03950. Epub 2019 Nov 14.
The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.
本文报道了一种使用甲磺酸/三乙胺三氢氟化物组合直接对烯丙基含底物进行氢氟化的方法。在使用易得、廉价且易于处理的试剂的无金属条件下，可以将一系列烯丙基烯烃转化为相应的叔氟化物，收率高达 78%。最后，还报道了该化学方法适应连续流动条件的有希望的结果。
