中国湖南抗逆转录病毒治疗中老年艾滋病毒感染者的认知障碍：一项横断面研究。
Cognitive Impairment Among Aging People Living With HIV on Antiretroviral Therapy: A Cross-Sectional Study in Hunan, China.
机构信息
Xueling Xiao, MSN, RN, is a PhD Student, Xiangya School of Nursing, Central South University, Hunan, China. Hui Zeng, PhD, RN, is a Professor, Xiangya School of Nursing, Central South University, Hunan, China. Caiyun Feng, BSN, RN, is a Postgraduate Student, Xiangya School of Nursing, Central South University, Hunan, China. Hang Tan, BSN, RN, is a Postgraduate Student, Xiangya School of Nursing, Central South University, Hunan, China. Lanlan Wu, BSN, RN, is a Postgraduate Student, Xiangya School of Nursing, Central South University, Hunan, China. Hui Zhang, BSN, RN, is a Postgraduate Student, Xiangya School of Nursing, Central South University, Hunan, China. Mary-Lynn Brecht, PhD, is Research Statistician and Adjunct Professor, University of California Los Angeles School of Nursing, Los Angeles, California, USA. Honghong Wang, PhD, RN, is Professor, Xiangya School of Nursing, Central South University, Hunan, China. Deborah Koniak-Griffin, RNC, EdD, FAAN, is Professor, Emerita and Audrienne H. Moseley Endowed Chair in Women's Health Research (on recall), University of California, Los Angeles, School of Nursing, Los Angeles, California, USA.
出版信息
J Assoc Nurses AIDS Care. 2020 May-Jun;31(3):301-311. doi: 10.1097/JNC.0000000000000122.
Our cross-sectional study examined the prevalence of cognitive impairment among people living with HIV (PLWH) aged 60 years or older. The sample, composed of 250 PLWH, was recruited from 2 clinics in Hunan, China. Structured questionnaires guided face-to-face interviews, including items addressing demographic characteristics, regimens of antiretroviral therapy, and cognitive status as measured by the Montreal Cognitive Assessment. Findings revealed cognitive function of this population was significantly lower than that of uninfected individuals based on historical comparisons; 87.2% (n = 218) of PLWH in our study had cognitive impairment. Global cognitive function as well as the domains of language and orientation decreased with age. Global cognitive function was associated with sex and education, but not with antiretroviral therapy regimens. These findings support an urgent need to include routine screening for cognitive function in older PLWH and the need to consider the complexity of the evaluation process.
本横断面研究调查了年龄在 60 岁及以上的 HIV 感染者（PLWH）中认知障碍的患病率。该样本由来自中国湖南的 2 家诊所的 250 名 PLWH 组成。通过结构化问卷进行面对面访谈，包括人口统计学特征、抗逆转录病毒治疗方案以及蒙特利尔认知评估测量的认知状态。研究结果显示，与历史对照相比，该人群的认知功能明显较低；在本研究中，87.2%（n = 218）的 PLWH 存在认知障碍。整体认知功能以及语言和定向领域的认知功能随年龄增长而下降。整体认知功能与性别和教育程度有关，但与抗逆转录病毒治疗方案无关。这些发现支持迫切需要在老年 PLWH 中常规筛查认知功能，并需要考虑评估过程的复杂性。
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