Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, United Kingdom.
Centre for Dementia Studies, University of Sussex, Falmer, East Sussex, United Kingdom.
PLoS One. 2021 May 19;16(5):e0251944. doi: 10.1371/journal.pone.0251944. eCollection 2021.
Quality of life (QoL) is recognized as an essential end point in the disease management of chronic conditions such as HIV with calls to include good QoL as a 'fourth 90' in the 90-90-90 testing and treatment targets introduced by World Health Organization in 2016. Cognitive impairments impact a broad spectrum of experiences and are a common issue effecting people living with HIV (PLWH). Despite this, few studies have examined QoL in PLWH who also have a cognitive disorder. This study aimed to synthesize and describe what is known about QoL in those living with HIV-associated neurocognitive disorders (HAND). A scoping review of peer-reviewed literature was conducted to identify how QoL has been investigated and measured in PLWH with HAND, and how PLWH with HAND report and describe their QoL. We searched PsychInfo, Medline, Scopus, and Web of Science along with hand-searching reference lists from relevant studies found. Included studies were those published in English after 1st January 2003 which included PLWH with cognitive impairment not due to other pre-existing conditions. Fifteen articles met criteria for inclusion. Two studies measured QoL as a primary aim, with others including QoL assessment as part of a broader battery of outcomes. The MOS-HIV and SF-36 were the most commonly used measures of overall QoL, with findings generally suggestive of poorer overall QoL in PLWH with HAND, compared to PLWH without cognitive impairment. Studies which examined dimensions of QoL focused exclusively on functionality, level of independence, and psychological QoL domains. There is a considerable dearth of research examining QoL in PLWH with HAND. The initiatives which advocate for healthy aging and improved QoL in PLWH must be extended to include and understand the experiences those also living with cognitive impairment. Research is needed to understand the broad experiential impacts of living with these two complex, chronic conditions, to ensure interventions are meaningful to patients and potential benefits are not missed.
生活质量（QoL）被认为是慢性疾病管理的重要终点，如艾滋病毒，呼吁将良好的 QoL 作为世界卫生组织 2016 年提出的 90-90-90 检测和治疗目标的“第四个 90”。认知障碍影响广泛的体验，是影响艾滋病毒感染者（PLWH）的常见问题。尽管如此，很少有研究检查同时患有认知障碍的 PLWH 的生活质量。本研究旨在综合描述和描述那些患有与艾滋病毒相关的神经认知障碍（HAND）的人的生活质量。对同行评议文献进行了范围审查，以确定在 HAND 患者中，生活质量是如何被调查和测量的，以及 HAND 患者如何报告和描述他们的生活质量。我们在 PsychInfo、Medline、Scopus 和 Web of Science 上进行了搜索，并从相关研究的参考文献中进行了手工搜索。纳入的研究是在 2003 年 1 月 1 日之后发表的英文研究，包括因其他先前存在的疾病以外的原因导致认知障碍的 PLWH。有 15 篇文章符合纳入标准。两项研究将生活质量作为主要目标进行测量，其他研究则将生活质量评估作为更广泛的结果测试套件的一部分。MOS-HIV 和 SF-36 是最常用的整体生活质量测量工具，与没有认知障碍的 PLWH 相比，HAND 患者的整体生活质量普遍较差。研究生活质量维度的研究专门关注功能、独立性水平和心理生活质量领域。研究 HAND 患者的生活质量的研究相当缺乏。倡导健康老龄化和改善 PLWH 生活质量的倡议必须扩大范围，包括并了解那些也患有认知障碍的人的生活体验。需要研究来了解同时患有这两种复杂慢性疾病的广泛体验影响，以确保干预措施对患者有意义，并且不会错过潜在的益处。
