Center for Disease Control and Prevention of PLA, Beijing, China.
Academy of Military Medical Sciences, Beijing, China.
Microb Drug Resist. 2020 May;26(5):492-496. doi: 10.1089/mdr.2019.0058. Epub 2019 Nov 15.
The spread of carbapenem-resistant has become a significant problem for public health in recent years. In this study, we reported a New Delhi metallo-β-lactamase 1 (NDM-1)-producing strain KP14003 from a neonate in Beijing, China. Whole-genome sequencing was performed. The strain belonged to sequence type ST719. Coexistence of and was found on a self-transferable plasmid, which had a typical IncX3 backbone. The horizontal transfer of was associated with Tn followed by possible transposition events. Other class A extended-spectrum β-lactamase genes ( and ) were also identified on chromosome or plasmid. The dissemination of NDM-1-producing causes great challenges to the treatment of clinical infections. Effective actions need to be taken to control the further spread of this pathogen.
近年来，碳青霉烯类耐药肠杆菌科细菌的传播对公共卫生造成了重大威胁。本研究报道了一株来自中国北京新生儿的产新德里金属β-内酰胺酶 1（NDM-1）肠杆菌科细菌 KP14003。进行了全基因组测序。该菌株属于序列型 ST719。在一个可自我转移的质粒上发现了 和 共存，该质粒具有典型的 IncX3 骨架。 的水平转移与 Tn 有关，随后可能发生转位事件。其他 A 类扩展谱β-内酰胺酶基因（和 ）也在染色体或质粒上被鉴定。产 NDM-1 肠杆菌科细菌的传播给临床感染的治疗带来了巨大挑战。需要采取有效措施来控制该病原体的进一步传播。
