2.0%（0.60mg/cm²）浓度的甲醛斑贴试验比 1.0%浓度的甲醛斑贴试验能检测出更多的甲醛接触过敏。

Patch Testing With Formaldehyde 2.0% (0.60 mg/cm2) Detects More Contact Allergy to Formaldehyde Than 1.0.

机构信息

From the Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmoe, Sweden.

Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo.

出版信息

Dermatitis. 2019 Nov/Dec;30(6):342-346. doi: 10.1097/DER.0000000000000510.

DOI:10.1097/DER.0000000000000510

PMID:31730552

Abstract

BACKGROUND

The International Contact Dermatitis Research Group increased the patch test concentration of formaldehyde from 1.0% aqueous (aq) to 2.0% aq (in 2011).

OBJECTIVE

This study was designed to investigate the outcome of the decision.

METHODS

Consecutive dermatitis patients in 8 different clinics were patch tested with formaldehyde 1.0% aq and 2.0% aq. The test solutions were applied with a micropipette to the filter paper discs in the respective chamber.

RESULTS

A total of 2778 patients were tested with 1.0% aq and 2766 to 2.0% aq. Sixty-five patients (2.3%, calculated from 2766 tested, to 2.0% aq) had positive patch test reactions interpreted as contact allergy to formaldehyde. This is a rather low frequency. Of these 65, 46 were women (46/1703 [2.7%]) and 19 were men (19/1063 [1.8%]). Thirty-six reacted only to 2.0% aq, 21 patients reacted to both concentrations, and 8 patients reacted only to 1.0% aq. Significantly, more patients reacted to 2.0% aq compared with 1.0% aq (P < 0.001). There was no significant sex difference. A total of 0.8% irritant reactions were recorded to formaldehyde 2.0% aq and 0.1% to 1.0% aq.

CONCLUSIONS

The increased formaldehyde patch test concentration to 2.0% aq revealed more formaldehyde contact allergy.

摘要

背景

国际接触性皮炎研究小组（International Contact Dermatitis Research Group）于 2011 年将甲醛的斑贴试验浓度从 1.0%水溶液（aq）增加到 2.0% aq。

目的

本研究旨在探讨这一决定的结果。

方法

在 8 家不同的诊所，连续的皮炎患者接受了 1.0% aq 和 2.0% aq 的甲醛斑贴试验。测试溶液通过微量移液器施加到相应腔室的滤纸片上。

结果

共有 2778 名患者接受了 1.0% aq 和 2766 至 2.0% aq 的测试。65 名患者（2.3%，从 2766 名测试者中计算得出，对 2.0% aq 呈阳性斑贴试验反应，解释为对甲醛的接触过敏）。这是一个相当低的频率。在这 65 名患者中，有 46 名是女性（46/1703 [2.7%]），19 名是男性（19/1063 [1.8%]）。36 名患者仅对 2.0% aq 有反应，21 名患者对两种浓度均有反应，8 名患者仅对 1.0% aq 有反应。值得注意的是，与 1.0% aq 相比，更多的患者对 2.0% aq 有反应（P < 0.001）。对 2.0% aq 的甲醛记录了 0.8%的刺激性反应，对 1.0% aq 的记录了 0.1%。