From the *Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö, Sweden; †Allergy Center and Department of Dermatology, University Hospital, Republic University of Uruguay, Montevideo; ‡Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark; §Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg; ∥Department of Dermatology, University Hospital Jena, Germany; ¶Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Belgium; #Department of Dermatology, National Skin Center, Singapore; **MGM Medical College, Kamothe, Mumbai, India; ††Department of Dermatology, UCSF School of Medicine, San Francisco, CA; ‡‡Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; §§Cutaneous Allergy Unit, St John's Institute of Dermatology, St Thomas Hospital, London, United Kingdom; ∥∥Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation, Melbourne, Victoria, Australia; and ¶¶Division of Dermatology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
Dermatitis. 2015 Sep-Oct;26(5):230-4. doi: 10.1097/DER.0000000000000137.
Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin included in most baseline patch test series.
The aims of this study were to investigate the contact allergy rate to PFR-2 in an international population and to investigate associated simultaneous allergic reactions.
Thirteen centers representing the International Contact Dermatitis Research Group included PFR-2 into their patch test baseline series during a period of 6 months in 2012.
Of 2259 patients tested, 28 (1.2%) reacted to PFR-2. Of those 28 individuals, one had a positive reaction to formaldehyde and 2 to p-tertiary-butylphenol-formaldehyde resin. Simultaneous allergic reactions were noted to colophonium in 3, to Myroxylon pereirae in 5, and to fragrance mix I in 8.
The contact allergy frequency in the tested population (1.2%) merits its inclusion into the international baseline series and possibly also into other baseline series after appropriate investigations. Significantly, overrepresented simultaneous allergic reactions were noted for M. pereirae and fragrance mix I.
基于苯酚和甲醛的酚醛树脂（PFR）引起的接触过敏，不会被大多数斑贴试验系列中包含的对叔丁基苯酚-甲醛树脂所检测到。
本研究旨在调查国际人群中对 PFR-2 的接触过敏率，并调查其相关的同时过敏反应。
2012 年的 6 个月期间，代表国际接触性皮炎研究小组的 13 个中心将 PFR-2 纳入其斑贴试验基础系列。
在 2259 名接受测试的患者中，有 28 名（1.2%）对 PFR-2 产生反应。在这 28 个人中，1 人对甲醛呈阳性反应，2 人对叔丁基苯酚-甲醛树脂呈阳性反应。同时还观察到对松香的过敏反应 3 例，对秘鲁香脂的过敏反应 5 例，对香料混合物 I 的过敏反应 8 例。
在测试人群中（1.2%）的接触过敏频率表明其有必要被纳入国际基础系列，并且在经过适当调查后，也可能被纳入其他基础系列。值得注意的是，同时过敏反应明显增多的是 M. pereirae 和香料混合物 I。
