Kabalka G W, Buonocore E, Hubner K, Davis M, Huang L
University of Tennessee Institute for Biomedical Imaging, Department of Radiology, Knoxville 37920.
Magn Reson Med. 1988 Sep;8(1):89-95. doi: 10.1002/mrm.1910080111.
Unique paramagnetic liposomal contrast agents were synthesized and utilized for selective augmentation of T1 MR imaging of the livers of normal Balb/c mice. Amphipathic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that they became an integral part of its surface. T1 signal enhancement of normal liver approached 150% after iv administration of the paramagnetic liposomes, determined by experiments performed on a 1.9-T, experimental whole-body MRI unit. Tracer studies utilizing gadolinium-153-tagged SUV revealed that the agents exhibited excellent in vivo stability, compared to liposomal preparations in which paramagnetic agents are simply entrapped in the aqueous core of the liposome vesicle.
合成了独特的顺磁性脂质体造影剂，并将其用于选择性增强正常Balb/c小鼠肝脏的T1磁共振成像。模拟磷脂的两亲性钆配合物被整合到小单层脂质体（SUV）的片层中，使其成为其表面的一个组成部分。通过在1.9-T实验性全身MRI设备上进行的实验测定，静脉注射顺磁性脂质体后，正常肝脏的T1信号增强接近150%。利用钆-153标记的SUV进行的示踪研究表明，与顺磁性剂简单包裹在脂质体囊泡水核中的脂质体制剂相比，这些造影剂在体内表现出优异的稳定性。
