Unger E C, Winokur T, MacDougall P, Rosenblum J, Clair M, Gatenby R, Tilcock C
Department of Radiology, Fox Chase Cancer Center, Philadelphia.
Radiology. 1989 Apr;171(1):81-5. doi: 10.1148/radiology.171.1.2928550.
Liposomal gadolinium diethylenetriaminepentaacetic acid (DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P less than .005) on T1-weighted MR images. Smaller 70-nm liposomal Gd-DTPA vesicles caused greater contrast enhancement, reflecting the larger surface-area-to-volume ratio of the smaller vesicles. Liposomal Gd-DTPA-enhanced images permitted significant improvement in metastasis detection by five blinded radiologists (P less than .005). By comparison, free Gd-DTPA without liposomes caused a statistically significant reduction in contrast between tumor and liver and reduced lesion detection (P less than .01). Liposomal Gd-DTPA also resulted in sustained vascular enhancement for 1 hour after administration. The results suggest that paramagnetic liposomes may become a useful MR imaging contrast agent.
包裹于70纳米和400纳米囊泡内的脂质体钆二乙烯三胺五乙酸（DTPA），被作为一种造影剂，用于对有肝转移的大鼠肝脏进行磁共振（MR）成像测试。脂质体钆-DTPA在T1加权MR图像上使肝脏与肿瘤之间的对比度显著改善（P<0.005）。较小的70纳米脂质体钆-DTPA囊泡引起更大的对比度增强，这反映了较小囊泡更大的表面积与体积比。脂质体钆-DTPA增强图像使五位不知情的放射科医生在转移灶检测方面有显著改善（P<0.005）。相比之下，无脂质体的游离钆-DTPA导致肿瘤与肝脏之间的对比度在统计学上显著降低，且病变检测减少（P<0.01）。脂质体钆-DTPA给药后还导致血管增强持续1小时。结果表明，顺磁性脂质体可能成为一种有用的MR成像造影剂。
