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Paramagnetic liposome nanoparticles for cellular and tumour imaging.

作者信息

Kamaly Nazila, Miller Andrew D

机构信息

Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, UK.

出版信息

Int J Mol Sci. 2010 Apr 15;11(4):1759-76. doi: 10.3390/ijms11041759.

DOI:10.3390/ijms11041759
PMID:20480040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2871136/
Abstract

In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/8ea2e6ae6d27/ijms-11-01759f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/2434ceaab869/ijms-11-01759f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/c3783df89678/ijms-11-01759f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/c3158f7dd152/ijms-11-01759f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/faa81d2823f2/ijms-11-01759f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/e1d2d628c987/ijms-11-01759f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/beaeddccb6fb/ijms-11-01759f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/6628962202f5/ijms-11-01759f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/8ea2e6ae6d27/ijms-11-01759f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/2434ceaab869/ijms-11-01759f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/c3783df89678/ijms-11-01759f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/c3158f7dd152/ijms-11-01759f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/faa81d2823f2/ijms-11-01759f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/e1d2d628c987/ijms-11-01759f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/beaeddccb6fb/ijms-11-01759f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/6628962202f5/ijms-11-01759f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/720b/2871136/8ea2e6ae6d27/ijms-11-01759f8.jpg

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本文引用的文献

[1]
Protective effect of PEGylation against poly(amidoamine) dendrimer-induced hemolysis of human red blood cells.

J Biomed Mater Res B Appl Biomater. 2010-4

[2]
A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI.

Org Biomol Chem. 2009-11-5

[3]
Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging.

Bioconjug Chem. 2009-4

[4]
Cellular compartmentalization of internalized paramagnetic liposomes strongly influences both T1 and T2 relaxivity.

Magn Reson Med. 2009-5

[5]
Three-compartment T1 relaxation model for intracellular paramagnetic contrast agents.

Magn Reson Med. 2009-5

[6]
Classification and basic properties of contrast agents for magnetic resonance imaging.

Contrast Media Mol Imaging. 2009

[7]
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.

Eur J Pharm Biopharm. 2009-6

[8]
Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement.

Int J Nanomedicine. 2008

[9]
Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes.

Dalton Trans. 2008-6-21

[10]
EPR characterization of gadolinium(III)-containing-PAMAM-dendrimers in the absence and in the presence of paramagnetic probes.

J Colloid Interface Sci. 2008-6-15

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