Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA.
Trends Immunol. 2019 Dec;40(12):1163-1179. doi: 10.1016/j.it.2019.10.002. Epub 2019 Nov 12.
Chronic inflammation in many infectious and metabolic diseases, and some cancers, is accompanied by the presence of foam cells. These cells form when the intracellular lipid content of macrophages exceeds their capacity to maintain lipid homeostasis. Concurrently, critical macrophage immune functions are diminished. Current paradigms of foam cell formation derive from studies of atherosclerosis. However, recent studies indicate that the mechanisms of foam cell biogenesis during tuberculosis differ from those operating during atherogenesis. Here, we review how foam cell formation and function vary with disease context. Since foam cells are therapeutic targets in atherosclerosis, further research on the disease-specific mechanisms of foam cell biogenesis and function is needed to explore the therapeutic consequences of targeting these cells in other diseases.
在许多传染性和代谢性疾病以及某些癌症中，慢性炎症伴随着泡沫细胞的存在。当巨噬细胞的细胞内脂质含量超过其维持脂质动态平衡的能力时，这些细胞就会形成。同时，巨噬细胞的关键免疫功能也会减弱。目前的泡沫细胞形成模式来源于动脉粥样硬化的研究。然而，最近的研究表明，在结核病中泡沫细胞生成的机制与动脉粥样硬化形成过程中的机制不同。在这里，我们综述了泡沫细胞的形成和功能如何随疾病背景而变化。由于泡沫细胞是动脉粥样硬化的治疗靶点，因此需要进一步研究泡沫细胞生成和功能的疾病特异性机制，以探讨在其他疾病中靶向这些细胞的治疗后果。
