Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Front Immunol. 2021 Dec 15;12:775326. doi: 10.3389/fimmu.2021.775326. eCollection 2021.
infects primarily macrophages in the lungs. Infected macrophages are surrounded by other immune cells in well organised structures called granulomata. As part of the response to TB, a type of macrophage loaded with lipid droplets arises which we call Foam cell macrophages. They are macrophages filled with lipid laden droplets, which are synthesised in response to increased uptake of extracellular lipids, metabolic changes and infection itself. They share the appearance with atherosclerosis foam cells, but their lipid contents and roles are different. In fact, lipid droplets are immune and metabolic organelles with emerging roles in Tuberculosis. Here we discuss lipid droplet and foam cell formation, evidence regarding the inflammatory and immune properties of foam cells in TB, and address gaps in our knowledge to guide further research.
主要感染肺部的巨噬细胞。受感染的巨噬细胞被其他免疫细胞包围在称为肉芽肿的组织中。作为对结核病反应的一部分，出现了一种负载脂滴的巨噬细胞，我们称之为泡沫细胞巨噬细胞。它们是充满富含脂质的液滴的巨噬细胞，这些液滴是对外界脂质摄取增加、代谢变化和感染本身的反应而合成的。它们的外观与动脉粥样硬化泡沫细胞相似，但它们的脂质含量和作用不同。事实上，脂滴是具有免疫和代谢功能的细胞器，在结核病中具有新的作用。在这里，我们讨论了脂滴和泡沫细胞的形成，以及关于结核病中泡沫细胞的炎症和免疫特性的证据，并解决了我们知识中的空白，以指导进一步的研究。
