除幽门螺杆菌外，胃微生物群有何关联？
What is the Relevance of Gastric Microbiota Beyond H. pylori?
作者信息
Schütte Kerstin, Malfertheiner Peter, Schulz Christian
机构信息
Department of Internal Medicine and Gastroenterology, Niels-Stensen-Kliniken, Marienhospital, Osnabrück, Germany.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University, Magdeburg, Germany.
出版信息
Curr Treat Options Gastroenterol. 2019 Dec;17(4):619-627. doi: 10.1007/s11938-019-00245-2.
PURPOSE
The role of Helicobacter pylori as key factor in gastric inflammation and the development of (pre-)cancerous lesions is undisputable. As an open system, the human upper gastrointestinal tract harbors a complex bacterial community which is highly impacted by the absence or presence of H. pylori. The interaction between other bacteria and H. pylori might impact on gastric carcinogenesis.
RECENT FINDINGS
Several studies demonstrated differences in the composition of the gastric bacterial community in different stages of gastritis and between samples from tumor and adjacent tissue. In addition, animal studies demonstrated an increased and accelerated development of precancerous lesions in mice colonized with intestinal flora and H. pylori compared with mice mono-infected with H. pylori.
CONCLUSION
Other bacteria beyond H. pylori enter the focus in research on gastric carcinogenesis. However, we are still far from a thorough understanding of the pathophysiology of host-microbiota interaction and its impact on the development of malignant and precancerous changes.
目的
幽门螺杆菌作为胃炎症及（癌前）病变发展的关键因素，其作用无可争议。作为一个开放系统，人类上消化道拥有一个复杂的细菌群落，该群落受到幽门螺杆菌存在与否的高度影响。其他细菌与幽门螺杆菌之间的相互作用可能会影响胃癌发生。
最新发现
多项研究表明，胃炎不同阶段以及肿瘤与相邻组织样本之间的胃细菌群落组成存在差异。此外，动物研究表明，与单纯感染幽门螺杆菌的小鼠相比，同时定植肠道菌群和幽门螺杆菌的小鼠癌前病变的发生增加且加速。
结论
除幽门螺杆菌外，其他细菌也成为胃癌发生研究的焦点。然而，我们对宿主-微生物群相互作用的病理生理学及其对恶性和癌前变化发展的影响仍远未完全理解。
Zotero 插件