Tziatzios Georgios, Gkolfakis Paraskevas, Papanikolaou Ioannis S, Mathur Ruchi, Pimentel Mark, Giamarellos-Bourboulis Evangelos J, Triantafyllou Konstantinos
Hepatogastroenterology Unit, Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Medical School, National and Kapodistrian University of Athens, "Attikon" University General Hospital, 124 62 Athens, Greece.
Department of Gastroenterology Hepatopancreatology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Microorganisms. 2020 May 8;8(5):691. doi: 10.3390/microorganisms8050691.
Functional dyspepsia (FD) is one of the most prevalent chronic functional gastrointestinal disorders. Several distinct pathophysiological mechanisms, including gastro duodenal motor disorders, visceral hypersensitivity, brain-gut interactions, duodenal subtle inflammation, and genetic susceptibility, have been implicated in the pathogenesis of the disease, so far. However, emerging evidence suggests that both quantitative and qualitative disturbances of the gastrointestinal microbiota may also be implicated. In this context, several studies have demonstrated differences of the commensal bacterial community between patients with FD and healthy controls, while others have shown that intestinal dysbiosis might associate with disease's symptoms severity. Elucidating these complex interactions constituting the microbiota and host crosstalk, may eventually lead to the discovery of novel, targeted therapeutic approaches that may be efficacious in treating the multiple aspects of the disorder. In this review, we summarize the data of the latest research with focus on the association between gut microbiota alterations and host regarding the pathogenesis of FD.
功能性消化不良（FD）是最常见的慢性功能性胃肠疾病之一。迄今为止，包括胃十二指肠运动障碍、内脏高敏感性、脑-肠相互作用、十二指肠微炎症和遗传易感性在内的几种不同的病理生理机制已被认为与该疾病的发病机制有关。然而，新出现的证据表明，胃肠道微生物群的数量和质量紊乱也可能与之相关。在这种背景下，多项研究已证实FD患者与健康对照者之间共生细菌群落存在差异，而其他研究则表明肠道菌群失调可能与疾病症状的严重程度相关。阐明构成微生物群与宿主相互作用的这些复杂相互作用，最终可能会发现新的、有针对性的治疗方法，这些方法可能对治疗该疾病的多个方面有效。在这篇综述中，我们总结了最新研究的数据，重点关注肠道微生物群改变与宿主在FD发病机制方面的关联。
