Al-Batayneh O B, Al-Rai S A, Khader Y S
Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan.
Department of Preventive Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan.
Eur Arch Paediatr Dent. 2020 Jun;21(3):339-346. doi: 10.1007/s40368-019-00490-0. Epub 2019 Nov 15.
The aim of this study was to assess the efficacy of CPP-ACP in reducing salivary S. mutans levels and compare its effect as a dentifrice to use of a fluoride dentifrice alone, or with the sequential use of a combination of both agents (fluoride, then CPP-ACP) in three groups of preschool children over a 6-month period.
This was a double-blinded clinical trial, the sample (n = 127, age 4.6 ± 0.47 years), with high caries risk, was randomized into three groups which applied different agents twice daily; fluoride toothpaste (500 ppm, n = 50), CPP-ACP (10% w/v, n = 38), and combination group (n = 39) applied fluoride, then CPP-ACP. S. mutans salivary levels were measured by GC Saliva-Check Mutans.
Within groups, a significant decrease in S. mutans-positive children (SMPC) occurred in fluoride and combination groups at 3-months, (P < 0.05), and in all groups at 6-months, (P < 0.05). The highest reduction in SMPC occurred in the CPP-ACP group, however, there were no significant differences in SMPC between groups at all study intervals, (P > 0.05).
Although all agents were effective, CPP-ACP showed the highest reduction in SMPC over 6-months.
本研究旨在评估酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP）降低唾液中变形链球菌水平的疗效，并在三组学龄前儿童中，比较其作为牙膏单独使用与使用含氟牙膏单独使用，或先后序贯使用两种制剂（先氟化物，后CPP-ACP）在6个月期间的效果。
这是一项双盲临床试验，样本（n = 127，年龄4.6±0.47岁）为高龋风险儿童，随机分为三组，每天两次使用不同制剂；含氟牙膏（500 ppm，n = 50）、CPP-ACP（10% w/v，n = 38），联合组（n = 39）先使用氟化物，再使用CPP-ACP。通过GC唾液变形链球菌检测试剂盒测量唾液中变形链球菌水平。
组内，氟化物组和联合组在3个月时变形链球菌阳性儿童（SMPC）显著减少（P < 0.05），所有组在6个月时均显著减少（P < 0.05）。SMPC减少最多的发生在CPP-ACP组，然而，在所有研究时间点，组间SMPC无显著差异（P > 0.05）。
尽管所有制剂均有效，但CPP-ACP在6个月内使SMPC减少最多。
