Tafti Samira Dehghani, Parisay Iman, Mehrabkhani Maryam, Sabbagh Sedigheh, Seddigh Sadaf, Ghazvini Kiarash, Daghestani Naeemeh
Department of Pediatric Dentistry, School of Dentistry, Mashhad University of Medical Sciences, Pittsburgh, PA, USA.
Dental Materials Research Center, School of Dentistry, Mashhad University of Medical Sciences, Pittsburgh, PA, USA.
Dent Res J (Isfahan). 2023 Nov 27;20:115. eCollection 2023.
Dental caries is a preventable multifactorial disease, with being suggested to be its primary pathogen. Our study aim was to compare the effects of three different low-cost and easy-to-use regimens with that of the gold standard (chlorhexidine [CHX] mouthwash) on the count of salivary in dental students over 30 days.
In this single-blinded parallel randomized controlled clinical trial, a total of 120 dental students were included and randomly allocated into four intervention groups: (1) CHX mouthwash (control(, (2) probiotic yogurt, (3) casein phosphopeptide-amorphous calcium phosphate chewing gum, and (4) xylitol chewing gum. Salivary counts were evaluated at baseline, 15 days, and 30 days after initiation of the study and compared at different times and among different groups using the repeated measures analysis of variance design analysis and least significant difference test with SPSS software version 20. The level of significance was determined to be 0.05.
The microorganism count variable at baseline, first, and second follow-ups was significantly different for all groups except the probiotic yogurt group ( = 0.340). count was significantly different when comparing the first follow-up and baseline values in the CHX and xylitol gum groups ( = 0.027, = 0.037). When comparing the second follow-up with baseline values, a significant difference was observed in the xylitol gum group ( = 0.003).
Xylitol chewing gum seems to be a viable alternative to the gold standard (CHX mouthwash) in reducing the salivary count of .
龋齿是一种可预防的多因素疾病， 被认为是其主要病原体。我们的研究目的是比较三种不同的低成本且易于使用的方案与金标准（氯己定[CHX]漱口水）对牙科学生唾液 计数在30天内的影响。
在这项单盲平行随机对照临床试验中，共纳入120名牙科学生，并随机分为四个干预组：（1）CHX漱口水（对照组），（2）益生菌酸奶，（3）酪蛋白磷酸肽 - 无定形磷酸钙口香糖，以及（4）木糖醇口香糖。在研究开始时、第15天和第30天评估唾液 计数，并使用SPSS 20版软件通过重复测量方差设计分析和最小显著差异检验在不同时间和不同组之间进行比较。显著性水平设定为0.05。
除益生菌酸奶组外（ = 0.340），所有组在基线、首次和第二次随访时的微生物计数变量均有显著差异。在CHX和木糖醇口香糖组中，比较首次随访和基线值时， 计数有显著差异（ = 0.027， = 0.037）。在木糖醇口香糖组中，比较第二次随访与基线值时，观察到显著差异（ = 0.003）。
在降低唾液 计数方面，木糖醇口香糖似乎是金标准（CHX漱口水）的可行替代品。
