Litvinov I S, Dolgikh D A
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Dokl Biol Sci. 2019 Sep;488(1):153-155. doi: 10.1134/S001249661905003X. Epub 2019 Nov 15.
Prolonged contact of healthy subjects with Mycobacterium tuberculosis can change their blood formula and immune status, thus reflecting adaptive reactions to constant antigenic load. The peripheral blood analysis of health care workers in a tuberculosis hospital demonstrates changes in cell populations which prevent development of tuberculosis, in particular, CD Т cells and CD Т cells. It is shown that the number of the memory CD Т cells specific to M.tuberculosis antigens which produce interferon gamma depends on the duration of work contact with tuberculosis patients. The use of health care workers' blood characteristics as a control for tuberculosis patients is discussed.
健康受试者与结核分枝杆菌的长期接触会改变其血液成分和免疫状态，从而反映出对持续抗原负荷的适应性反应。对一家结核病医院医护人员的外周血分析表明，细胞群体发生了变化，这些变化可预防结核病的发生，尤其是CD Т细胞和CD Т细胞。结果表明，产生γ干扰素的结核分枝杆菌抗原特异性记忆CD Т细胞的数量取决于与结核病患者工作接触的时长。文中还讨论了将医护人员的血液特征用作结核病患者对照的情况。
