Division of Pulmonary, Critical Care and Sleep Medicine, The Warren Alpert School of Medicine at Brown University, Providence, RI, USA; Division of Pulmonary, Critical Care & Sleep Medicine, Rhode Island Hospital, POB Suite 224, 595 Eddy Street, Providence, RI 02903, USA.
Division of Pulmonary, Critical Care and Sleep Medicine, The Warren Alpert School of Medicine at Brown University, Providence, RI, USA; Division of Pulmonary, Critical Care & Sleep Medicine, Rhode Island Hospital, POB Suite 224, 595 Eddy Street, Providence, RI 02903, USA.
Crit Care Clin. 2020 Jan;36(1):105-113. doi: 10.1016/j.ccc.2019.08.008.
Metabolomics is an emerging field of research interest in sepsis. Metabolomics provides new ways of exploring the diagnosis, mechanism, and prognosis of sepsis. Advancements in technologies have enabled significant improvements in identifying novel biomarkers associated with the disease progress of sepsis. The use of metabolomics in the critically ill may provide new approaches to enable precision medicine. Furthermore, the dynamic interactions of the host and its microbiome can lead to further progression of sepsis. Understanding these interactions and the changes in the host's genomics and the microbiome can provide novel preventive and therapeutic strategies against sepsis.
代谢组学是脓毒症研究领域的一个新兴分支。代谢组学为脓毒症的诊断、发病机制和预后提供了新的研究途径。技术的进步使我们能够更准确地识别与脓毒症疾病进展相关的新型生物标志物。将代谢组学应用于危重病患者可能为精准医学提供新的方法。此外，宿主与其微生物组的动态相互作用可能导致脓毒症的进一步恶化。了解这些相互作用以及宿主基因组和微生物组的变化可以为脓毒症提供新的预防和治疗策略。
