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Synaptonemal complex damage induced by clastogenic and anti-mitotic chemicals: implications for non-disjunction and aneuploidy.

作者信息

Allen J W, Gibson J B, Poorman P A, Backer L C, Moses M J

机构信息

Genetic Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.

出版信息

Mutat Res. 1988 Oct;201(2):313-24. doi: 10.1016/0027-5107(88)90020-6.

DOI:10.1016/0027-5107(88)90020-6
PMID:3173380
Abstract

Mice were treated with mitomycin C, cyclophosphamide, amsacrine, colchicine, or vinblastine sulfate, and meiotic prophase cells analyzed for synaptonemal complex (SC) damage. All test agents caused synaptonemal complex breakage and synapsis irregularities, although propensities for inducing specific types of damage at S-phase or prophase stages varied among the chemicals. The data indicate that SC analysis can reveal chemical-specific alterations to meiotic homologue pairing/synapsis which have not generally been recognized, and which theoretically may be implicated in non-disjunction.

摘要

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