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Synaptonemal complex damage as a measure of genotoxicity at meiosis.

作者信息

Allen J W, Poorman P A, Backer L C, Gibson J B, Westbrook-Collins B, Moses M J

机构信息

Genetic Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

出版信息

Cell Biol Toxicol. 1988 Dec;4(4):487-94. doi: 10.1007/BF00117776.

DOI:10.1007/BF00117776
PMID:3228716
Abstract

Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.

摘要

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本文引用的文献

1
Synaptonemal complex analysis of mouse chromosomal rearrangements. III. Cytogenetic observations on two paracentric inversions.小鼠染色体重排的联会复合体分析。III. 对两个臂内倒位的细胞遗传学观察
Chromosoma. 1981;83(3):419-29. doi: 10.1007/BF00327363.
2
Synaptonemal complex analysis of mouse chromosomal rearrangements. I. Cytogenetic observations on a tandem duplication.小鼠染色体重排的联会复合体分析。I. 关于串联重复的细胞遗传学观察
Chromosoma. 1981;81(4):507-18. doi: 10.1007/BF00285846.
3
Synaptonemal complexes as indicators of induced structural change in chromosomes after irradiation of spermatogonia.
小鼠减数分裂染色体上错配修复蛋白的定位表明其在减数分裂前期I具有不同功能。
J Cell Biol. 2005 Nov 7;171(3):447-58. doi: 10.1083/jcb.200506170. Epub 2005 Oct 31.
4
Aneuploidy induced by cyclophosphamide in developing rat testes.
In Vitro Cell Dev Biol Anim. 1998 Jan;34(1):11-3. doi: 10.1007/s11626-998-0042-9.
5
Cisplatin increases meiotic crossing-over in mice.顺铂可增加小鼠减数分裂过程中的交叉互换。
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8681-5. doi: 10.1073/pnas.94.16.8681.
Mutat Res. 1983 Nov;122(2):149-54. doi: 10.1016/0165-7992(83)90053-2.
4
Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). IV. Light and electron microscopy of synapsis and nucleolar development by silver staining.中国仓鼠（黑线仓鼠）精母细胞的联会复合体核型分析。IV. 银染法对联会和核仁发育的光镜和电镜观察
Chromosoma. 1980;76(1):1-22. doi: 10.1007/BF00292222.
5
Differentiation of the synaptonemal complex and the kinetochore in Locusta spermatocytes studied by whole mount electron microscopy.通过整装电子显微镜研究蝗虫精母细胞中联会复合体和动粒的分化。
Chromosoma. 1973 Nov 21;44(2):231-53. doi: 10.1007/BF00329119.
6
Chromosome aberrations in F1 from irradiated male mice studied by their synaptonemal complexes.通过联会复合体研究受辐照雄性小鼠F1代中的染色体畸变。
Mutat Res. 1986 May;174(1):59-65. doi: 10.1016/0165-7992(86)90077-1.
7
Synaptonemal complex damage in relation to meiotic chromosome aberrations after exposure of male mice to cyclophosphamide.雄性小鼠暴露于环磷酰胺后，联会复合体损伤与减数分裂染色体畸变的关系。
Mutat Res. 1988 Aug;203(4):317-30. doi: 10.1016/0165-1161(88)90021-0.
8
Synaptonemal complex damage induced by clastogenic and anti-mitotic chemicals: implications for non-disjunction and aneuploidy.
Mutat Res. 1988 Oct;201(2):313-24. doi: 10.1016/0027-5107(88)90020-6.
9
Synaptonemal complex damage as a measure of chemical mutagen effects on mammalian germ cells.
Mutat Res. 1987 Jan;190(1):19-24. doi: 10.1016/0165-7992(87)90076-5.
10
Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome.唐氏综合征中21号不分离染色体上重组减少的证据。
Science. 1987 Aug 7;237(4815):652-4. doi: 10.1126/science.2955519.