Loidl J
Department of Cytology and Genetics, University of Vienna, Wien, Austria.
Exp Cell Res. 1988 Sep;178(1):93-7. doi: 10.1016/0014-4827(88)90381-3.
Interference of colchicine with meiotic chromosome pairing in the wild garlic, Allium ursinum, was studied using a whole-mount spreading technique for synaptonemal complexes. Colchicine was found to cause (i) pairing suppression (arrest of leptotene) and (ii) deficient pairing initiation at zygotene in connection with morphologically anomalous, malfunctioning pairing initiation sites. Both of these phenomena could be responsible for the reduction of chiasma frequency by colchicine previously reported in the literature.
