School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China; Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China.
School of Medical Imaging, Xuzhou Medical University, Xuzhou 221004, China.
Colloids Surf B Biointerfaces. 2020 Jan 1;185:110625. doi: 10.1016/j.colsurfb.2019.110625. Epub 2019 Nov 8.
Multifunctional nanocarriers, which can be used for molecular imaging and drug delivery simultaneously, favor the fabrication of theranostic platforms in a less cost- and time-consuming way. Polyethylene glycol (PEG)-modified manganese dioxide (MnO) nanosheets (PEG-MnO), used as two-dimensional nanomaterials, not only possess the high surface-to-volume ratio necessary for drug delivery but also display a redoxable property in the tumor microenvironment, producing Mn ions for magnetic resonance imaging (MRI). In this study, we constructed a PEG-MnO-OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo. This strategy of utilizing PEG-MnO nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T-weight MRI, illustrating the promising potential of PEG-MnO nanosheets for the fabrication of an MRI-based theranostic system.
多功能纳米载体，可同时用于分子成像和药物输送，有利于以更低的成本和更短的时间构建治疗诊断一体化平台。聚乙二醇（PEG）修饰的二氧化锰（MnO）纳米片（PEG-MnO）作为二维纳米材料，不仅具有药物输送所需的高表面积与体积比，而且在肿瘤微环境中还表现出可氧化还原的特性，产生用于磁共振成像（MRI）的 Mn 离子。在这项研究中，我们通过模块化链霉亲和素桥构建了一种 PEG-MnO-OPN siRNA 纳米复合物，用于体外和体内肾癌细胞的治疗诊断。这种利用 PEG-MnO 纳米片进行 OPN siRNA 递药的策略，显著抑制了 786-O 荷瘤小鼠的肿瘤生长，并且这一过程可以通过激活的 T1 加权 MRI 进行监测，表明 PEG-MnO 纳米片在构建基于 MRI 的治疗诊断一体化系统方面具有广阔的应用前景。
