• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于二氧化锰的纳米材料在肿瘤诊断和治疗领域的研究进展。

Progress of Nanomaterials Based on Manganese Dioxide in the Field of Tumor Diagnosis and Therapy.

机构信息

Department of Pharmacy, Hejiang County People's Hospital, Luzhou, Sichuan, People's Republic of China.

Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Aug 29;19:8883-8900. doi: 10.2147/IJN.S477026. eCollection 2024.

DOI:10.2147/IJN.S477026
PMID:39224196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11368147/
Abstract

As a pivotal transition metal oxide, manganese dioxide (MnO) has garnered significant attention owing to its abundant reserves, diverse crystal structures and exceptional performance. Nanosizing MnO results in smaller particle sizes, larger specific surface areas, optimized material characteristics, and expanded application possibilities. With the burgeoning research efforts in this field, MnO has emerged as a promising nanomaterial for tumor diagnosis and therapy. The distinctive properties of MnO in regulating the tumor microenvironment (TME) have attracted considerable interest, leading to a rapid growth in research on MnO-based nanomaterials for tumor diagnosis and treatment. Additionally, MnO nanomaterials are also gradually showing up in the regulation of chronic inflammatory diseases. In this review, we mainly summarized the recent advancements in various MnO nanomaterials for tumor diagnosis and therapy. Furthermore, we discuss the current challenges and future directions in the development of MnO nanomaterials, while also envisaging their potential for clinical translation.

摘要

作为一种重要的过渡金属氧化物，二氧化锰（MnO）由于其丰富的储量、多样的晶体结构和卓越的性能而受到广泛关注。MnO 的纳米化导致颗粒尺寸更小、比表面积更大、材料特性得到优化和应用可能性得到扩展。随着该领域研究的蓬勃发展，MnO 已成为肿瘤诊断和治疗的一种很有前途的纳米材料。MnO 调节肿瘤微环境（TME）的独特性质引起了人们的极大兴趣，导致基于 MnO 的纳米材料在肿瘤诊断和治疗方面的研究迅速增长。此外，MnO 纳米材料也逐渐出现在慢性炎症性疾病的调节中。在这篇综述中，我们主要总结了各种用于肿瘤诊断和治疗的 MnO 纳米材料的最新进展。此外，我们还讨论了 MnO 纳米材料发展中当前的挑战和未来方向，同时也展望了它们在临床转化中的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/3cae609abe71/IJN-19-8883-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/e723d9347fec/IJN-19-8883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/208015e06c40/IJN-19-8883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/b699eab5a8b6/IJN-19-8883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/30ffa55bb9eb/IJN-19-8883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/65211246216e/IJN-19-8883-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/3cae609abe71/IJN-19-8883-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/e723d9347fec/IJN-19-8883-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/208015e06c40/IJN-19-8883-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/b699eab5a8b6/IJN-19-8883-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/30ffa55bb9eb/IJN-19-8883-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/65211246216e/IJN-19-8883-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4be/11368147/3cae609abe71/IJN-19-8883-g0006.jpg

相似文献

1
Progress of Nanomaterials Based on Manganese Dioxide in the Field of Tumor Diagnosis and Therapy.基于二氧化锰的纳米材料在肿瘤诊断和治疗领域的研究进展。
Int J Nanomedicine. 2024 Aug 29;19:8883-8900. doi: 10.2147/IJN.S477026. eCollection 2024.
2
Manganese Dioxide-Based Nanomaterials for Medical Applications.基于二氧化锰的纳米材料在医疗中的应用。
ACS Biomater Sci Eng. 2024 May 13;10(5):2680-2702. doi: 10.1021/acsbiomaterials.3c01852. Epub 2024 Apr 8.
3
Manganese dioxide (MnO) based nanomaterials for cancer therapies and theranostics.基于二氧化锰（MnO）的纳米材料在癌症治疗和诊断中的应用。
J Drug Target. 2021 Nov;29(9):911-924. doi: 10.1080/1061186X.2020.1815209. Epub 2021 Aug 20.
4
Recent advances in functionalized MnO nanosheets for biosensing and biomedicine applications.功能化 MnO 纳米片在生物传感和生物医学应用中的最新进展。
Nanoscale Horiz. 2019 Mar 1;4(2):321-338. doi: 10.1039/c8nh00274f. Epub 2018 Nov 29.
5
Biomedical applications of MnO nanomaterials as nanozyme-based theranostics.基于 MnO 纳米材料纳米酶的生物医学应用：诊断与治疗一体化。
Biomed Pharmacother. 2023 Jul;163:114833. doi: 10.1016/j.biopha.2023.114833. Epub 2023 May 8.
6
Manganese dioxide nanosheets: from preparation to biomedical applications.二氧化锰纳米片：从制备到生物医学应用。
Int J Nanomedicine. 2019 Jul 3;14:4781-4800. doi: 10.2147/IJN.S207666. eCollection 2019.
7
Multifunctional Smart Yolk-Shell Nanostructure with Mesoporous MnO Shell for Enhanced Cancer Therapy.具有介孔MnO壳层的多功能智能蛋黄壳纳米结构用于增强癌症治疗
ACS Appl Mater Interfaces. 2020 Sep 2;12(35):38906-38917. doi: 10.1021/acsami.0c08389. Epub 2020 Aug 20.
8
MnO-Based nanosystems for cancer therapy.基于 MnO 的纳米系统用于癌症治疗。
Chem Commun (Camb). 2020 Jul 4;56(52):7065-7079. doi: 10.1039/d0cc02782k. Epub 2020 Jun 4.
9
Reversing Hypoxia with PLGA-Encapsulated Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response to Tumor Spheroids.载锰二氧化物纳米粒的聚乳酸-乙醇酸逆转缺氧改善自然杀伤细胞对肿瘤球体的反应。
Mol Pharm. 2021 Aug 2;18(8):2935-2946. doi: 10.1021/acs.molpharmaceut.1c00085. Epub 2021 Jun 30.
10
Multifunctional MnO nanoparticles for tumor microenvironment modulation and cancer therapy.多功能 MnO 纳米粒子用于肿瘤微环境调节和癌症治疗。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Nov;13(6):e1720. doi: 10.1002/wnan.1720. Epub 2021 Apr 27.

引用本文的文献

1
Thermoresponsive NDP hydrogel embedded with MnO nanoparticles for postoperative antirecurrence therapy in pancreatic cancer.嵌入MnO纳米颗粒的热响应性NDP水凝胶用于胰腺癌术后抗复发治疗。
Sci Rep. 2025 Jul 2;15(1):23570. doi: 10.1038/s41598-025-08431-2.
2
Golden insights for exploring cancer: delivery, from genes to the human body using bimetallic Au/Ag nanostructures.探索癌症的宝贵见解：利用双金属金/银纳米结构从基因到人体的传递
Discov Oncol. 2025 May 25;16(1):918. doi: 10.1007/s12672-025-02714-w.
3
A hollow nanozyme-based multifunctional platform enhances sonodynamic-chemodynamic-induced ferroptosis for cancer therapy.

本文引用的文献

1
Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme-Like Catalysis.用于癌症治疗的二氧化锰包覆压电纳米声敏剂：肿瘤微环境重塑与多酶样催化作用
Small Methods. 2024 Dec;8(12):e2400018. doi: 10.1002/smtd.202400018. Epub 2024 Apr 1.
2
Remodeling Tumor Immune Microenvironment by Using Polymer-Lipid-Manganese Dioxide Nanoparticles with Radiation Therapy to Boost Immune Response of Castration-Resistant Prostate Cancer.利用聚合物-脂质-二氧化锰纳米颗粒联合放射治疗重塑肿瘤免疫微环境以增强去势抵抗性前列腺癌的免疫反应
Research (Wash D C). 2023 Oct 3;6:0247. doi: 10.34133/research.0247. eCollection 2023.
3
基于中空纳米酶的多功能平台增强声动力-化学动力诱导的铁死亡用于癌症治疗。
RSC Adv. 2025 Mar 27;15(12):9408-9419. doi: 10.1039/d5ra00032g. eCollection 2025 Mar 21.
Redox/pH-responsive hollow manganese dioxide nanoparticles for thyroid cancer treatment.
用于甲状腺癌治疗的氧化还原/ pH响应性中空二氧化锰纳米颗粒
Front Chem. 2023 Sep 15;11:1249472. doi: 10.3389/fchem.2023.1249472. eCollection 2023.
4
Preparation of Biocompatible Manganese Selenium-Based Nanoparticles with Antioxidant and Catalytic Functions.具有抗氧化和催化功能的生物相容性锰硒基纳米粒子的制备。
Molecules. 2023 Jun 1;28(11):4498. doi: 10.3390/molecules28114498.
5
Biomedical applications of MnO nanomaterials as nanozyme-based theranostics.基于 MnO 纳米材料纳米酶的生物医学应用：诊断与治疗一体化。
Biomed Pharmacother. 2023 Jul;163:114833. doi: 10.1016/j.biopha.2023.114833. Epub 2023 May 8.
6
Alleviating the hypoxic tumor microenvironment with MnO-coated CeO nanoplatform for magnetic resonance imaging guided radiotherapy.用 MnO 涂层的 CeO 纳米平台缓解缺氧肿瘤微环境，用于磁共振成像引导的放射治疗。
J Nanobiotechnology. 2023 Mar 15;21(1):90. doi: 10.1186/s12951-023-01850-1.
7
Dual-Oxygenation/Dual-Fenton Synergistic Photothermal/Chemodynamic/Starvation Therapy for Tumor Treatment.用于肿瘤治疗的双氧合/双芬顿协同光热/化学动力学/饥饿疗法
ACS Appl Mater Interfaces. 2023 Mar 29;15(12):15129-15139. doi: 10.1021/acsami.2c22578. Epub 2023 Mar 14.
8
Manganese oxide-modified bismuth oxychloride piezoelectric nanoplatform with multiple enzyme-like activities for cancer sonodynamic therapy.具有多种类酶活性的氧化锰修饰氯氧化铋压电纳米平台用于癌症声动力治疗
J Colloid Interface Sci. 2023 Jun 15;640:839-850. doi: 10.1016/j.jcis.2023.03.008. Epub 2023 Mar 7.
9
Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma.植酸修饰的二氧化锰纳米粒子低聚物用于骨肉瘤的磁共振成像和靶向治疗。
Drug Deliv. 2023 Dec;30(1):2181743. doi: 10.1080/10717544.2023.2181743.
10
Nucleus-Targeting Manganese Dioxide Nanoparticles Coated with the Human Umbilical Cord Mesenchymal Stem Cell Membrane for Cancer Cell Therapy.靶向细胞核的人脐带间充质干细胞膜包裹的二氧化锰纳米颗粒用于癌细胞治疗。
ACS Appl Mater Interfaces. 2023 Mar 1;15(8):10541-10553. doi: 10.1021/acsami.3c01176. Epub 2023 Feb 14.