Department of Research Microbes Evolution Phylogeny and Infections (MEPHI), The Institute for Development Research (IRD), University Hospital Institute-Mediterranean infection, Aix Marseille University, 19-21 Boulevard Jean MOULIN, 13005 Marseille, France.
J Infect. 2020 Feb;80(2):161-166. doi: 10.1016/j.jinf.2019.11.003. Epub 2019 Nov 14.
Reliable non-invasive methods for measuring body temperature are essential for the diagnosis and monitoring of infectious disease.
This study used Intraclass Correlation Coefficients (ICC) and the Bland- Altman plot to analyse the agreement between temperature measurements using an ingestible capsule sensor, a skin sensor and two non-invasive peripheral temperature measurements (axillary and infrared non-contact), collected from a population of febrile patient admitted for infectious disease.
Of the 77 febrile patients screened, 26 patients were enrolled. The ICC between axillary temperature measurements (Taxi) vs. non-contact measurements (Tno-c) were 0.34 [-0.18; 0.63], 0.87 [0.55; 0.94] between Taxi vs. ingestible capsule measurements (Tcap) and 0.12 [-0.09; 0.37] between Taxi vs. Tetac. The mean difference between Taxi vs Tno-c was -1.18 °C with limits of agreement (LoA) from -2.96 to 0.58 °C. The mean difference between Taxi vs Tcap was 0.48 °C, with LoA from -0.60 to 1.56 °C. The mean difference between Taxi vs Tetac was -4.23 °C with LoA from -7.22 to -1.23 °C.
Ingestible capsule measurements are reliable enough to adequately estimate the core body temperature in clinical practice. Its non-invasiveness, and the real-time remote control offer new opportunities for future research into fever during infectious diseases.
可靠的非侵入性体温测量方法对于传染病的诊断和监测至关重要。
本研究使用组内相关系数（ICC）和 Bland- Altman 图分析了从发热患者人群中采集的可摄入胶囊传感器、皮肤传感器和两种非侵入性外周温度测量（腋窝和红外非接触式）测量的体温之间的一致性。
在筛选的 77 名发热患者中，有 26 名患者入组。腋窝温度测量（Taxi）与非接触式测量（Tno-c）之间的 ICC 为 0.34 [-0.18; 0.63]，Taxi 与可摄入胶囊测量（Tcap）之间的 ICC 为 0.87 [0.55; 0.94]，Taxi 与 Tetac 之间的 ICC 为 0.12 [-0.09; 0.37]。Taxi 与 Tno-c 之间的平均差异为-1.18°C，其一致性区间（LoA）为-2.96 至 0.58°C。Taxi 与 Tcap 之间的平均差异为 0.48°C，其 LoA 为-0.60 至 1.56°C。Taxi 与 Tetac 之间的平均差异为-4.23°C，其 LoA 为-7.22 至-1.23°C。
可摄入胶囊测量足以可靠地估计临床实践中的核心体温。它的非侵入性以及实时远程控制为未来研究传染病期间的发热提供了新的机会。
