Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal; Faculty of Medicine, University of Porto (FMUP), Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal; Research Department, LPCC-Portuguese League against Cancer- Northern Branch (Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte), Estrada Interior da Circunvalação 6657, 4200-172 Porto, Portugal.
Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal.
Crit Rev Oncol Hematol. 2019 Dec;144:102825. doi: 10.1016/j.critrevonc.2019.102825. Epub 2019 Nov 2.
There has been a shift in the paradigm of Non-Hodgkin lymphomas, changing from the classical genetic aberration-based model to a more complex and dynamic model involving tumor microenvironment interactions. In this instance, exosomes have emerged as important mediators in intercellular communication by providing survival and proliferation signals, licensing immune evasion and acquisition of drug resistance. The capability to transfer molecular cargo made exosomes a focus of research to understand cancer pathogenesis and its progression pathways. Several studies identified exosomes transporting tumor-released components in peripheral blood and focused on understanding their clinical relevance in the diagnosis, prognostic and in monitoring cancer progression. Moreover, due to their biophysical properties and physiological function, exosomes have drawn attention as potential therapeutic target and drug delivery vehicles. This review will discuss the function of exosomes in Non-Hodgkin lymphomagenesis, highlight their potential as diagnosis and prognosis biomarkers, and as new therapeutic opportunities in lymphoma management.
非霍奇金淋巴瘤的范式已经发生转变，从基于经典遗传异常的模型转变为更复杂和动态的模型，涉及肿瘤微环境相互作用。在这种情况下，外泌体通过提供生存和增殖信号、许可免疫逃逸和获得耐药性，成为细胞间通讯的重要介质。外泌体能够传递分子货物，这使它们成为研究的焦点，以了解癌症的发病机制及其进展途径。有几项研究确定了在外周血液中运输肿瘤释放成分的外泌体，并专注于了解其在诊断、预后和监测癌症进展中的临床相关性。此外，由于其生物物理特性和生理功能，外泌体作为潜在的治疗靶点和药物递送载体引起了关注。这篇综述将讨论外泌体在非霍奇金淋巴瘤发生中的作用，强调它们作为诊断和预后生物标志物的潜力，以及作为淋巴瘤管理中新的治疗机会。
