Pediatric Oncology Department, Regina Margherita Children's Hospital, AOU Città della Salute e della Scienza di Torino, Turin, Italy.
Cancer Genomics and Bioinformatics Unit, Italian Institute for Genomic Medicine, Torino, Italy.
Pediatr Blood Cancer. 2020 Feb;67(2):e28072. doi: 10.1002/pbc.28072. Epub 2019 Nov 17.
Over the last decade, next-generation sequencing technologies have improved our ability to assess biological aspects, at genomic and transcriptomic levels, on a large scale- and have been increasingly used for the management of adult cancers. However, their efficacy and feasibility within pediatrics is still under investigation. "Omic" approaches represent an opportunity to understand the oncogenic mechanisms driving the onset and progression of bone sarcoma and improve the clinical management of young patients with bone sarcomas. This review focuses on the current genomic and transcriptomic characteristics of managing pediatric patients, affected by Ewing sarcoma and osteosarcoma.
在过去的十年中，下一代测序技术提高了我们在基因组和转录组水平上大规模评估生物学方面的能力，并越来越多地用于成人癌症的治疗。然而，它们在儿科中的疗效和可行性仍在研究中。“组学”方法为了解驱动骨肉瘤发生和进展的致癌机制提供了机会，并改善了骨肉瘤患儿的临床管理。这篇综述重点介绍了目前管理患有尤文肉瘤和骨肉瘤的儿科患者的基因组和转录组特征。
