Department of Environmental Safety and Ecotoxicology, Szent István University, Gödöllő, Hungary.
Department of Phage Typing and Molecular Epidemiology, National Center for Epidemiology, Budapest, Hungary.
Int J Environ Health Res. 2021 Nov;31(7):848-860. doi: 10.1080/09603123.2019.1691719. Epub 2019 Nov 18.
is a major public health concern all around the world. In the frame of this work, a set of diverse environmental isolates with various antibiotic resistance profiles were examined in a virulence model. Motility, serotypes, virulence factors and biofilm-forming ability were also examined. Molecular types were determined by pulsed-field gel electrophoresis (PFGE). Based on our results, the majority of environmental isolates were virulent in the test and twitching showed a positive correlation with mortality. Resistance against several antibiotic agents such as Imipenem correlated with a lower virulence in the applied model. PFGE revealed that five examined environmental isolates were closely related to clinically detected pulsed-field types. Our study demonstrated that industrial wastewater effluents, composts, and hydrocarbon-contaminated sites should be considered as hot spots of high-risk clones of
是全世界主要的公共卫生关注点。在这项工作的框架内，我们在一个毒性模型中检查了一组具有不同抗生素耐药谱的不同环境分离物。运动性、血清型、毒力因子和生物膜形成能力也进行了检查。分子类型通过脉冲场凝胶电泳 (PFGE) 确定。根据我们的结果，大多数环境分离物在测试中具有毒性，而抽动与死亡率呈正相关。对几种抗生素药物（如亚胺培南）的耐药性与应用模型中的低毒性相关。PFGE 显示，所检查的五种环境分离物与临床上检测到的脉冲场类型密切相关。我们的研究表明，工业废水、堆肥和受碳氢化合物污染的地点应被视为高危克隆的热点
