Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Maternal Fetal Medicine Division, Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA.
J Matern Fetal Neonatal Med. 2021 Oct;34(20):3393-3396. doi: 10.1080/14767058.2019.1685969. Epub 2019 Nov 17.
To investigate the perinatal outcomes of fetuses with antenatal diagnoses of intra-abdominal umbilical vein varix (UVV).
A multicenter retrospective study was conducted in four countries on fetuses diagnosed with intra-abdominal UVV between 2012 and 2019. Collected data included gestational age (GA), UVV maximum diameter at diagnosis and delivery, associated anatomical and chromosomal anomalies, birth weight, and neonatal outcomes.
Twenty fetuses were identified, of which 20% had associated chromosomal and/or anatomical abnormalities, most resulting in poor outcomes (either intrauterine fetal death or pregnancy termination). Mean maternal age was 34.1 ± 7.0 years, UVV was diagnosed at 26.5 ± 4.5 weeks of GA on average with a maximum diameter of 12.0 ± 4.0 mm. Mean GA at delivery was 35.4 ± 5.6 weeks. Survival rate was 85%.
Our study shows a satisfactory outcome when intra-abdominal UVV is an isolated finding, with minimal obstetrical and perinatal consequences. The prognosis is worse when UVV is associated with other anomalies.
探讨产前诊断为腹腔内脐静脉静脉瘤（UVV）的胎儿的围产结局。
对 2012 年至 2019 年间在四个国家/地区诊断为腹腔内 UVV 的胎儿进行了一项多中心回顾性研究。收集的数据包括胎龄（GA）、诊断和分娩时的 UVV 最大直径、相关的解剖和染色体异常、出生体重和新生儿结局。
共确定了 20 例胎儿，其中 20%存在相关的染色体和/或解剖异常，导致不良结局（宫内胎儿死亡或终止妊娠）的比例较高。母亲的平均年龄为 34.1±7.0 岁，UVV 平均在 GA 26.5±4.5 周时诊断，最大直径为 12.0±4.0mm。平均分娩 GA 为 35.4±5.6 周。存活率为 85%。
当腹腔内 UVV 为孤立性发现时，本研究显示出满意的结局，对产科和围产结局的影响较小。当 UVV 与其他异常相关时，预后更差。
