Milardi Demetrio, Quartarone Angelo, Bramanti Alessia, Anastasi Giuseppe, Bertino Salvatore, Basile Gianpaolo Antonio, Buonasera Piero, Pilone Giorgia, Celeste Giuseppe, Rizzo Giuseppina, Bruschetta Daniele, Cacciola Alberto
Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, Messina, Italy.
IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.
Front Syst Neurosci. 2019 Oct 30;13:61. doi: 10.3389/fnsys.2019.00061. eCollection 2019.
Much of our present understanding of the function and operation of the basal ganglia rests on models of anatomical connectivity derived from tract-tracing approaches in rodents and primates. However, the last years have been characterized by promising step forwards in the investigation and comprehension of brain connectivity in humans. The aim of this review is to revise the current knowledge on basal ganglia circuits, highlighting similarities and differences across species, in order to widen the current perspective on the intricate model of the basal ganglia system. This will allow us to explore the implications of additional direct pathways running from cortex to basal ganglia and between basal ganglia and cerebellum recently described in animals and humans.
我们目前对基底神经节功能和运作的许多理解都基于从啮齿动物和灵长类动物的神经束追踪方法得出的解剖学连接模型。然而，过去几年的特点是在人类大脑连接性的研究和理解方面取得了有前景的进展。这篇综述的目的是修订关于基底神经节回路的现有知识，突出不同物种之间的异同，以拓宽目前对基底神经节系统复杂模型的认识。这将使我们能够探讨最近在动物和人类中描述的从皮层到基底神经节以及基底神经节与小脑之间的额外直接通路的影响。
