皮质醇对肾上腺切除大鼠下丘脑室旁核神经元的抑制作用；一项体外研究。
Inhibition by cortisol of neurons in the paraventricular nucleus of the hypothalamus in adrenalectomized rats; an in vitro study.
作者信息
Kasai M, Yamashita H
机构信息
Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
出版信息
Neurosci Lett. 1988 Aug 15;91(1):59-64. doi: 10.1016/0304-3940(88)90249-2.
The effects of cortisol on neurons in the parvocellular division of the paraventricular nucleus (PVN) were investigated in hypothalamic slices prepared from adrenalectomized (ADX) and intact rats. In ADX rats, cortisol inhibited 14 (21%) out of 68 PVN neurons tested at a concentration of 10(-5) M and 11 (16%) of 69 PVN neurons tested at a concentration of 10(-4) M. In intact rats, cortisol at concentrations of 10(-5) M and 10(-4) M did not change the activity of most PVN neurons tested. We conclude that cortisol has an inhibitory effect on neurons in the parvocellular division of the PVN in ADX rats.
在由肾上腺切除（ADX）大鼠和完整大鼠制备的下丘脑切片中，研究了皮质醇对室旁核（PVN）小细胞部神经元的影响。在ADX大鼠中，皮质醇在浓度为10^(-5) M时抑制了68个受试PVN神经元中的14个（21%），在浓度为10^(-4) M时抑制了69个受试PVN神经元中的11个（16%）。在完整大鼠中，浓度为10^(-5) M和10^(-4) M的皮质醇并未改变大多数受试PVN神经元的活性。我们得出结论，皮质醇对ADX大鼠PVN小细胞部的神经元具有抑制作用。
Zotero 插件