皮质醇抑制去甲肾上腺素诱导的室旁核神经元兴奋性反应：一项体外研究。
Cortisol suppresses noradrenaline-induced excitatory responses of neurons in the paraventricular nucleus; an in vitro study.
作者信息
Kasai M, Yamashita H
机构信息
Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
出版信息
Neurosci Lett. 1988 Aug 15;91(1):65-70. doi: 10.1016/0304-3940(88)90250-9.
The effects of cortisol on noradrenaline (NA)-induced responses of neurons in the parvocellular division of the paraventricular nucleus (PVN) were investigated in hypothalamic slices of rats. Cortisol (10(-5) M)-induced excitation in 7 out of 11 PVN neurons tested and inhibited 3 out of 8 PVN neurons which were not affected by NA. Cortisol alone did not affect the basal firing rate of the PVN neurons. We conclude that cortisol may have an inhibitory effect on neurons in the parvocellular division of the PVN through depression of the noradrenergic system.
在大鼠下丘脑切片中研究了皮质醇对室旁核（PVN）小细胞部神经元去甲肾上腺素（NA）诱导反应的影响。皮质醇（10⁻⁵ M）在11个受试PVN神经元中的7个中诱导兴奋，并在8个不受NA影响的PVN神经元中的3个中产生抑制作用。单独使用皮质醇不影响PVN神经元的基础放电率。我们得出结论，皮质醇可能通过抑制去甲肾上腺素能系统对PVN小细胞部的神经元产生抑制作用。
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