离子电渗法施加皮质醇对麻醉大鼠下丘脑室旁核结节漏斗神经元的影响。

Effects of iontophoretically applied cortisol on tuberoinfundibular neurons in hypothalamic paraventricular nucleus of anesthetized rats.

作者信息

Kasai M, Kannan H, Ueta Y, Osaka T, Inenaga K, Yamashita H

机构信息

Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

出版信息

Neurosci Lett. 1988 Apr 22;87(1-2):35-40. doi: 10.1016/0304-3940(88)90141-3.

DOI:10.1016/0304-3940(88)90141-3

PMID:3380340

Abstract

Effects of cortisol on 22 tuberoinfundibular (TI) neurons in the paraventricular nucleus (PVN) of the hypothalamus were examined in urethane-anesthetized rats. Iontophoretically applied cortisol excited 10 (45%) of 22 TI-neurons tested, whereas the cortisol inhibited 4 (31%) of 13 neurons in the periventricular hypothalamic nucleus. Intravenously applied cortisol (0.5 mg in 0.5 ml saline) excited 4 (36%) of 11 TI neurons tested and inhibited 1 (9%). These results suggest that cortisol may have an excitatory effect on TI neurons in the PVN.

摘要

在氨基甲酸乙酯麻醉的大鼠中，研究了皮质醇对下丘脑室旁核（PVN）中22个结节漏斗（TI）神经元的影响。通过离子电渗法施加皮质醇，在22个被测试的TI神经元中，有10个（45%）被兴奋，而在下丘脑室周核中，皮质醇抑制了13个神经元中的4个（31%）。静脉注射皮质醇（0.5毫克溶于0.5毫升盐水中），在11个被测试的TI神经元中，有4个（36%）被兴奋，1个（9%）被抑制。这些结果表明，皮质醇可能对PVN中的TI神经元有兴奋作用。