Jampel H D, Morrison J, Vocci M, Quigley H
Glaucoma Service, Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland.
Ophthalmic Surg. 1988 Aug;19(8):576-9.
We have localized fibrin/fibrinogen in experimental glaucoma filtration surgery wounds in non-human primates by light and transmission electron microscopy. Fibrin/fibrinogen was abundant two days after surgery, but was virtually undetectable by seven days postoperatively. We have confirmed the identity of fibrin/fibrinogen on the ultrastructural level by immunoelectron microscopy employing antibodies directed against fibrinogen. Fibrin clot formation may play an important role in the wound healing response that causes glaucoma filtration surgery to fail.
我们通过光学显微镜和透射电子显微镜，在非人类灵长类动物的实验性青光眼滤过手术伤口中定位了纤维蛋白/纤维蛋白原。术后两天纤维蛋白/纤维蛋白原含量丰富，但术后七天几乎检测不到。我们通过使用针对纤维蛋白原的抗体进行免疫电子显微镜检查，在超微结构水平上证实了纤维蛋白/纤维蛋白原的特性。纤维蛋白凝块形成可能在导致青光眼滤过手术失败的伤口愈合反应中起重要作用。
