Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue Box 22, New York, NY 10065, USA.
Department of Radiation Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA.
Hematol Oncol Clin North Am. 2020 Feb;34(1):1-12. doi: 10.1016/j.hoc.2019.08.014. Epub 2019 Oct 15.
A series of landmark studies have increasingly emphasized the role of adjuvant radiotherapy for the definitive management of breast cancer. Although regional nodal irradiation, including the internal mammary nodes, was typically reserved for high-risk patients, there is now evidence of benefit to this approach even for those with a limited nodal disease burden. Similarly, low-risk disease has historically been treated with whole-breast tangents, although contemporary studies now support accelerated partial breast irradiation or the omission of radiotherapy in select cases. This article presents recent data informing these contemporary developments in the radiotherapeutic management of breast cancer.
一系列具有里程碑意义的研究越来越强调辅助放疗在乳腺癌确定性治疗中的作用。尽管区域淋巴结照射，包括内乳淋巴结，通常保留给高危患者，但现在有证据表明这种方法对那些淋巴结疾病负担有限的患者也有获益。同样，低危疾病既往采用全乳切线照射，但目前的研究支持在某些情况下采用加速部分乳腺照射或省略放疗。本文介绍了这些乳腺癌放射治疗管理方面的当代进展所依据的最新数据。
