Department of Radiation Oncology, Seattle Cancer Care Alliance Proton Therapy Center, University of Washington School of Medicine, 1570 North 115th Street, Seattle, WA 98133, USA.
Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Hematol Oncol Clin North Am. 2020 Feb;34(1):127-142. doi: 10.1016/j.hoc.2019.08.020. Epub 2019 Oct 28.
Radiation therapy plays a critical role in the management of a wide range of hematologic malignancies. The optimal radiation dose and target volume, and safe and effective ways of integrating radiation with systemic agents, vary depending on the histologic subtypes, stage at presentation, patient performance status, response to systemic therapy if given, treatment intent, and patient preferences. Limiting doses to surrounding organs without sacrificing disease control is of paramount importance. Reducing radiation doses and treatment volume in selected cases, and the use of advanced radiotherapy technology, can improve the therapeutic ratio of patients receiving radiation therapy for hematologic malignancies.
放射治疗在多种血液系统恶性肿瘤的治疗中起着至关重要的作用。最佳的放射剂量和靶区，以及安全有效的将放射治疗与全身药物联合应用的方法，取决于组织学亚型、就诊时的分期、患者的体能状态、如果给予全身治疗的反应、治疗目的以及患者的偏好。在不影响疾病控制的情况下，限制周围器官的剂量至关重要。在某些情况下降低放射剂量和治疗体积，以及使用先进的放射治疗技术，可以提高接受放射治疗的血液系统恶性肿瘤患者的治疗效果。
