头颈部癌症放射治疗的演变角色。

The Evolving Role of Radiotherapy for Head and Neck Cancer.

机构信息

Department of Radiation Oncology, UTHSC College of Medicine, 1265 Union Avenue, Memphis, TN 38104, USA; Department of Preventive Medicine, UTHSC College of Medicine, 1265 Union Avenue, Memphis, TN 38104, USA.

Hematology/Oncology, Department of Medicine, UTHSC College of Medicine, 19 South Manassas Street, Cancer Research Building, 324, Memphis, TN 38103, USA; Department of Genetics/Genomics/Informatics, UTHSC College of Medicine, Memphis, TN, USA; Department of Preventive Medicine, UTHSC College of Medicine, Memphis, TN, USA; Department of Pathology, UTHSC College of Medicine, Memphis, TN, USA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

出版信息

Hematol Oncol Clin North Am. 2020 Feb;34(1):91-108. doi: 10.1016/j.hoc.2019.08.019. Epub 2019 Oct 15.

DOI:10.1016/j.hoc.2019.08.019

PMID:31739954

Abstract

The length and quality of head and neck cancer survivorship continues to meaningfully improve. Radiotherapy has been central to this process through advances in treatment delivery, fractionation schemas, radiosensitizing systemic therapy, and thoughtful interplay with technical surgical improvements. The future looks brighter still, with ongoing progress in targeted biologic therapy, immuno-oncology, and molecular-genetic tumor characterization for personalized treatment. Head and neck cancer, a disease once fraught with nihilism and failure, is evolving into a major success story of modern multidisciplinary cancer care.

摘要

头颈部癌症的生存长度和质量继续得到显著改善。通过治疗方式的进步、分割方案、放射增敏全身治疗以及与技术手术改进的深思熟虑的相互作用，放射治疗在这一过程中发挥了核心作用。随着靶向生物治疗、免疫肿瘤学和分子遗传学肿瘤特征分析的不断进展，为个体化治疗提供了可能，未来的前景更加光明。头颈部癌症曾是一种充满虚无主义和失败的疾病，但现在正在演变成现代多学科癌症治疗的一个主要成功案例。