人巨细胞病毒编码的 microRNAs：潜伏感染的主要调节因子。

Human cytomegalovirus-encoded MicroRNAs: A master regulator of latent infection.

机构信息

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia; Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.

Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Omdurman, Sudan.

出版信息

Infect Genet Evol. 2020 Mar;78:104119. doi: 10.1016/j.meegid.2019.104119. Epub 2019 Nov 15.

DOI:10.1016/j.meegid.2019.104119

PMID:31740397

Abstract

Human cytomegalovirus (HCMV) can modulate the host cell microenvironment to cause latent infection and is therefore considered a major health concern in immunocompromised patients. HCMV-encoded microRNAs (miRs) have emerged as a key player in regulating the expression of the host cell and viral genes to induce latent infection. HCMV-encoded miRs can inhibit antiviral immune responses, such as proinflammatory mediators production, antigenic presentation, and apoptosis. In addition, HCMV miRs can reduce viral DNA replication. In this review, we describe the mechanisms underlying HCMV-encoded miR-mediated regulation of latent infection that may be exploited for future designing novel miRs-directed therapies.

摘要

人类巨细胞病毒（HCMV）可以调节宿主细胞微环境，导致潜伏感染，因此被认为是免疫功能低下患者的主要健康问题。HCMV 编码的 microRNAs（miRs）已成为调节宿主细胞和病毒基因表达以诱导潜伏感染的关键因素。HCMV 编码的 miRs 可以抑制抗病毒免疫反应，例如产生促炎介质、抗原呈递和细胞凋亡。此外，HCMV miRs 可以减少病毒 DNA 复制。在这篇综述中，我们描述了 HCMV 编码的 miR 介导的潜伏感染调节的机制，这可能为未来设计新型 miR 靶向治疗提供依据。