Borthen Svinhufvud L, Heimdahl A, Nord C E
Department of Oral Surgery, Karolinska Institute, Huddinge, Sweden.
Oral Surg Oral Med Oral Pathol. 1988 Sep;66(3):304-9. doi: 10.1016/0030-4220(88)90236-8.
In a crossover study the effect of local vancomycin (paste containing 0.5% vancomycin applied to the gums three times a day for 7 days) versus chlorhexidine mouth rinsing (0.2% chlorhexidine solution twice a day for 7 days) on alpha-hemolytic streptococci in the oral cavity was investigated in eight volunteers. Mixed saliva and dental plaque samples were collected for microbiologic analysis before administration, during treatment, and after withdrawal of the agents. The numbers of different alpha-hemolytic streptococci were determined in the samples. The total numbers of Streptococcus mitior, Streptococcus mutans, and Streptococcus sanguis were significantly reduced by the vancomycin treatment compared with the chlorhexidine treatment (p less than 0.05) after 2 days of administration. Two days after the treatment was stopped the numbers of alpha-hemolytic streptococci had returned to pretreatment levels. Local prophylaxis with vancomycin as a complement to systemic antimicrobial prophylaxis may therefore be useful in the prevention of infective endocarditis.
在一项交叉研究中，对8名志愿者研究了局部应用万古霉素（含0.5%万古霉素的糊剂，每天三次涂抹于牙龈，持续7天）与洗必泰漱口（0.2%洗必泰溶液，每天两次，持续7天）对口腔内甲型溶血性链球菌的影响。在给药前、治疗期间和停药后收集混合唾液和牙菌斑样本进行微生物分析。测定样本中不同甲型溶血性链球菌的数量。给药2天后，与洗必泰治疗相比，万古霉素治疗使缓症链球菌、变形链球菌和血链球菌的总数显著减少（p<0.05）。停药两天后，甲型溶血性链球菌的数量已恢复到治疗前水平。因此，局部应用万古霉素作为全身抗菌预防的补充，可能有助于预防感染性心内膜炎。
