Carr Francis, Tan Kimberley, Stevenson William, Ahmad Kate
Department of Neurology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Northern Clinical School, University of Sydney, St Leonards, New South Wales, Australia.
Neuroophthalmology. 2018 Aug 23;43(5):313-317. doi: 10.1080/01658107.2018.1508303. eCollection 2019 Nov.
We report a case of an 18-year-old woman presenting with headache, papilloedema, and cerebrospinal fluid (CSF) pleocytosis. She was subsequently diagnosed with acute myeloid leukaemia, which is to date the only reported case manifesting as central nervous system-localised disease in an adult. The intracranial hypertension was treated successfully with chemotherapy, acetazolamide, and CSF drainage, with no permanent visual impairment. The mechanism by which haematological malignancy causes intracranial hypertension is not fully elucidated, but we hypothesise that in our case, blast infiltration interfered with CSF reabsorption at the arachnoid granulations.
我们报告了一例18岁女性患者，其表现为头痛、视乳头水肿和脑脊液（CSF）细胞增多。她随后被诊断为急性髓系白血病，这是迄今为止报道的唯一一例在成人中表现为中枢神经系统局限性疾病的病例。通过化疗、乙酰唑胺和脑脊液引流成功治疗了颅内高压，未造成永久性视力损害。血液系统恶性肿瘤导致颅内高压的机制尚未完全阐明，但我们推测在我们的病例中，原始细胞浸润干扰了蛛网膜颗粒处的脑脊液重吸收。
