Hersi Reem M, Aldosari Ayat M, Naaman Nada K, Alrajhi Rawan K, Alqahtani Abdullah S
Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.
Ophthalmology, King Abdulaziz Medical City, Jeddah, Saudi Arabia, Jeddah, SAU.
Cureus. 2022 May 27;14(5):e25413. doi: 10.7759/cureus.25413. eCollection 2022 May.
Leukemia is a malignant hematologic neoplastic disease in which acquired mutations and genetic abnormalities in early hematopoietic precursors cause rapid proliferation of white blood cells (WBC). Acute myeloid leukemia (AML), a subtype of leukemia, is a rare form of cancer that typically manifests in adulthood. Symptoms typically arise due to abnormal proliferation of WBC. Ocular manifestations of such malignancies are rare and they occur more commonly in acute lymphoblastic leukemia (ALL) rather than AML. Furthermore, ophthalmic involvement usually is either a sign of central nervous system involvement or disease relapse. In this article, we report the case of a 14-year-old girl who presented initially with double vision and right eye squint. The patient was later diagnosed with AML with leptomeningeal involvement.
白血病是一种恶性血液肿瘤性疾病，其中早期造血前体细胞获得性突变和基因异常导致白细胞（WBC）快速增殖。急性髓系白血病（AML）是白血病的一种亚型，是一种罕见的癌症形式，通常在成年期出现。症状通常由于白细胞异常增殖而产生。此类恶性肿瘤的眼部表现罕见，且在急性淋巴细胞白血病（ALL）中比在AML中更常见。此外，眼部受累通常是中枢神经系统受累或疾病复发的迹象。在本文中，我们报告了一名14岁女孩的病例，她最初表现为复视和右眼斜视。该患者后来被诊断为伴有软脑膜受累的AML。
