Priest Andrew Vae, Koirala Ramesh, Sivasankar Sanjeevi
Department of Biomedical Engineering, University of California, Davis, CA 95616.
Department of Physics and Astronomy, Iowa State University, Ames, IA 50011.
Curr Opin Biomed Eng. 2019 Dec;12:43-50. doi: 10.1016/j.cobme.2019.08.006. Epub 2019 Sep 28.
Classical cadherin and desmosomal cadherin cell-cell adhesion proteins play essential roles in tissue morphogenesis and in maintaining tissue integrity. Deficiencies in cadherin adhesion are hallmarks of diseases like cancers, skin diseases and cardiomyopathies. Structural studies and single molecule biophysical measurements have revealed critical similarities and surprising differences between these key adhesion proteins. This review summarizes our current understanding of the biophysics of classical and desmosomal cadherin adhesion and the molecular basis for their cross-talk. We focus on recent single molecule measurements, highlight key insights into the adhesion of cadherin extracellular regions and their relation to associated diseases, and identify major open questions in this exciting area of research.
经典钙黏蛋白和桥粒钙黏蛋白这类细胞间黏附蛋白在组织形态发生和维持组织完整性方面发挥着重要作用。钙黏蛋白黏附功能的缺陷是癌症、皮肤病和心肌病等疾病的特征。结构研究和单分子生物物理测量揭示了这些关键黏附蛋白之间的关键相似性和惊人差异。本综述总结了我们目前对经典钙黏蛋白和桥粒钙黏蛋白黏附生物物理学及其相互作用分子基础的理解。我们关注最近的单分子测量，强调对钙黏蛋白细胞外区域黏附的关键见解及其与相关疾病的关系，并确定这一令人兴奋的研究领域中的主要未解决问题。
