Department of Biology, University of Detroit Mercy, Detroit, Michigan 48221; email:
Annu Rev Pathol. 2018 Jan 24;13:51-70. doi: 10.1146/annurev-pathol-020117-044030.
Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly and junctional integrity are required to maintain the overall homeostasis of a tissue, organ, and organism. This review discusses the desmosome and the human diseases associated with its disruption.
组织完整性对于维持生物体的内稳态至关重要。影响细胞-细胞接触部位的异常可导致多种使人虚弱的疾病。桥粒是组织中承受压力的重要细胞-细胞连接蛋白复合物，它协调细胞内信号转导。桥粒的组装和连接完整性对于维持组织、器官和生物体的整体内稳态是必需的。本文讨论了桥粒及其与破坏相关的人类疾病。
