Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy , Sichuan University , Chengdu 610041 , China.
J Org Chem. 2019 Dec 20;84(24):16286-16292. doi: 10.1021/acs.joc.9b02468. Epub 2019 Dec 3.
An efficient synthetic method to construct -indole derivatives has been successfully developed involving rhodium-catalyzed highly selective C-H bond activation of -phenylbenzimidamides and subsequent couplings with pyridotriazoles. This cascade approach features excellent chemoselectivity and unique of products containing quaternary carbon center with the pyridyl moiety.
已成功开发出一种有效的合成方法来构建吲哚衍生物，涉及铑催化的 - 苯基苯并咪唑酰胺的高选择性 C-H 键活化，以及随后与吡啶并三唑的偶联。这种级联方法具有出色的化学选择性和独特的产物，其中包含带有吡啶基部分的季碳原子中心。
