Department of Invasive Cardiology, Medical University of Bialystok, Białystok, Poland.
Department of Invasive Cardiology, Medical University of Bialystok, Białystok, Poland
Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15064. Epub 2019 Nov 19.
Air pollution is a documented risk factor for cardiovascular diseases.
The aim of the study was to assess the effect of air pollution on the number of hospital admissions for acute coronary syndrome (ACS) in elderly patients.
The medical records of 26 695 patients hospitalized for ACS between 2008 and 2017 were examined. Weather conditions and the following components of air pollution were analyzed: sulfur dioxide, nitrogen dioxide, and particulate matter with a diameter of 2.5 μm or less (PM2.5) and a diameter of 10 μm or less (PM10).
The study included 1618 inhabitants of Białystok in Poland (mean [SD] age, 75 [6.4] years; men, 52.6%). The norm for PM2.5 was exceeded on 23.5% of days, while for PM10, on 5.3% of days. Elevated PM10 levels were associated with a higher number of hospitalizations for ACS on the day of exposure (mean [SD], 0.61 [0.78] vs 0.44 [0.69]; P <0.001), and this effect persisted in the subsequent days (mean [SD], 1.07 [1.07] vs 0.88 [1.00]; P = 0.02). An increase of PM10 concentrations by 10 μg/m3 was associated with an increase in the number of hospitalizations due to unstable angina, and significant effects were observed even after 6 days (rate ratio, 1.16; 95% CI, 1.03-1.32; P = 0.02).
Increased exposure to air pollution, in particular, elevated PM10 levels, is associated with a higher incidence of ACS both on the day of exposure and over the following days.
空气污染是心血管疾病的已证实危险因素。
本研究旨在评估空气污染对老年急性冠状动脉综合征（ACS）住院人数的影响。
研究分析了 2008 年至 2017 年间因 ACS 住院的 26695 名患者的病历。分析了天气状况和以下几种空气污染成分：二氧化硫、二氧化氮以及直径为 2.5μm 或以下（PM2.5）和直径为 10μm 或以下（PM10）的颗粒物。
研究纳入了波兰比亚韦斯托克的 1618 名居民（平均[标准差]年龄 75[6.4]岁；男性占 52.6%）。PM2.5 超标天数占 23.5%，PM10 超标天数占 5.3%。暴露日 PM10 水平升高与 ACS 住院人数增加相关（平均[标准差]，0.61[0.78] vs 0.44[0.69]；P<0.001），这种影响在随后几天仍持续存在（平均[标准差]，1.07[1.07] vs 0.88[1.00]；P=0.02）。PM10 浓度增加 10μg/m3 与不稳定型心绞痛导致的住院人数增加相关，甚至在 6 天后仍观察到显著影响（发病率比，1.16；95%置信区间，1.03-1.32；P=0.02）。
暴露于空气污染，尤其是 PM10 水平升高，与暴露日以及随后几天 ACS 发病率升高相关。
