Department of Invasive Cardiology, Medical University of Bialystok, The Medical University of Bialystok Clinical Hospital, ul. M. Skłodowskiej-Curie 24 A, 15-276, Bialystok, Poland.
Department of Invasive Cardiology, Medical University of Bialystok, The Medical University of Bialystok Clinical Hospital, ul. M. Skłodowskiej-Curie 24 A, 15-276, Bialystok, Poland.
Int J Hyg Environ Health. 2020 Aug;229:113578. doi: 10.1016/j.ijheh.2020.113578. Epub 2020 Aug 3.
This study aimed to assess the effect of air pollution and weather conditions on the frequency of hospital admissions due to acute coronary syndrome (ACS) in the population of Bialystok, known as the capital of the Green Lungs of Poland.
The study analyzed the medical records of 2,645 patients living within the borders of Bialystok who were treated for ACS between 2009 and 2017 and the data on air pollutants-nitrogen dioxide (NO), sulfur dioxide (SO), and particulate matter with a diameter of 2.5 μm or less (PM) and 10 μm or less (PM)-and the basic meteorological factors (temperature, humidity, and atmospheric pressure). A time-stratified case-crossover study design was applied to assess the effects of particulate matter, the concentration of gases, and weather conditions on ACS.
The number of patients admitted for ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA) was 791, 999, and 855, respectively. The daily concentration norm for PM recommended by the World Health Organization (WHO) was exceeded in 692 days (i.e., 24.58% of the observation period). The significant increase in the number of ACS hospitalizations was associated with an interquartile-range increase in NO concentration, with an odds ratio of 1.08 (95% confidence interval (CI): 1.02-1.15, P = 0.01), 1.09 (95% CI: 1.01-1.18, P = 0.03), and 1.11 (95% CI: 1.00-1.22, P = 0.048) for patients with ACS, NSTEMI, and UA, respectively.
The study showed that the effects of air pollution and weather conditions on the number of ACS hospitalizations are also observed in cities with moderately polluted or good air quality. NO was identified as the main air pollutant affecting the incidence of ACS.
本研究旨在评估空气污染和天气条件对波兰“绿肺之都”比亚韦斯托克市人群因急性冠状动脉综合征（ACS）住院频率的影响。
本研究分析了 2009 年至 2017 年间在比亚韦斯托克市边界内接受 ACS 治疗的 2645 名患者的医疗记录，以及有关空气污染物（二氧化氮（NO）、二氧化硫（SO）和直径为 2.5μm 或以下（PM）和 10μm 或以下（PM）的颗粒物）和基本气象因素（温度、湿度和大气压力）的数据。采用时间分层病例交叉研究设计来评估颗粒物、气体浓度和天气条件对 ACS 的影响。
因 ST 段抬高型心肌梗死、非 ST 段抬高型心肌梗死（NSTEMI）和不稳定型心绞痛（UA）住院的患者人数分别为 791、999 和 855。世界卫生组织（WHO）推荐的 PM 日浓度标准在 692 天内超标（即观察期的 24.58%）。ACS 住院人数的显著增加与 NO 浓度的四分位距增加相关，比值比（OR）分别为 1.08（95%置信区间（CI）：1.02-1.15，P=0.01）、1.09（95% CI：1.01-1.18，P=0.03）和 1.11（95% CI：1.00-1.22，P=0.048），分别适用于 ACS、NSTEMI 和 UA 患者。
该研究表明，在空气污染程度中等或空气质量良好的城市，空气污染和天气条件对 ACS 住院人数的影响也存在。NO 被确定为影响 ACS 发病率的主要空气污染物。
