Divisions of Nuclear Medicine, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa.
Ophthalmology, Tygerberg Hospital and Stellenbosch University, Cape Town, South Africa.
Ocul Immunol Inflamm. 2021 Apr 3;29(3):530-536. doi: 10.1080/09273948.2019.1685109. Epub 2019 Nov 19.
: To determine the utility of fluorine-18 fluorodeoxyglucose Positron Emission Tomography Computed Tomography (FDG PET/CT) in patients with suspected ocular sarcoidosis (OS) or intraocular tuberculosis (IOTB) in a resource-constrained, TB endemic area.: Independent review of the FDG PET/CTs, Computed Tomography (CT) scans and chest radiographs (CXRs) of patients with suspected OS or IOTB and inconclusive conventional workup.: Twenty-nine PET/CTs and CXRs were reviewed, with 38% of PET/CTs and CTs demonstrating evidence of TB or sarcoidosis, compared to 21% of CXRs. The sensitivity, specificity, positive and negative predictive values for PET/CT and CT were similar - 85.7%, 95.5%, 85.7% and 95.5% for OS, and 33.3%, 100%, 100% and 68% for IOTB respectively and for CXR, 57.1%, 100%, 100% and 88% for OS, and 16.7%, 100%, 100% and 63% for IOTB.: PET/CT added no significant additional benefit over Chest CT in patients with suspected OS or IOTB.
在资源有限且结核病流行的地区，评估氟-18 氟代脱氧葡萄糖正电子发射断层扫描计算机断层扫描（FDG PET/CT）在疑似眼结节病（OS）或眼内结核（IOTB）患者中的效用。
对疑似 OS 或 IOTB 患者的 FDG PET/CT、计算机断层扫描（CT）和胸部 X 光片（CXR）进行独立评估，且常规检查结果不确定。
共回顾了 29 例 PET/CT 和 CXR，与 CXR 的 21%相比，38%的 PET/CT 和 CT 显示有 TB 或结节病的证据。PET/CT 和 CT 的灵敏度、特异性、阳性和阴性预测值相似-OS 分别为 85.7%、95.5%、85.7%和 95.5%，IOTB 分别为 33.3%、100%、100%和 68%，CXR 分别为 57.1%、100%、100%和 88%，OS 分别为 16.7%、100%、100%和 63%。
对于疑似 OS 或 IOTB 患者，PET/CT 与胸部 CT 相比并未显著增加额外获益。
