Testi Ilaria, Agrawal Rupesh, Mehta Salil, Basu Soumvaya, Nguyen Quan, Pavesio Carlos, Gupta Vishali
Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom.
Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom; National Healthcare Group Eye Institute, Tan Tock Seng Hospital; Singapore Eye Research Institute, Singapore.
Indian J Ophthalmol. 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20.
Diagnosis and management of ocular tuberculosis (OTB) poses a significant challenge. Mixed ocular tissue involvement and lack of agreement on best practice diagnostic tests together with the global variations in therapeutic management contributed to the existing uncertainties regarding the outcome of the disease. The current review aims to update recent progress on OTB. In particular, the Collaborative Ocular Tuberculosis Study (COTS) group recently standardized a nomenclature system for defining clinical phenotypes, and also proposed consensus guidelines and an algorithmic approach for management of different clinical phenotypes of OTB. Recent developments in experimental research and innovations in molecular diagnostics and imaging technology have provided a new understanding in the pathogenesis and natural history of the disease.
眼结核（OTB）的诊断和管理面临重大挑战。眼部组织混合受累、最佳实践诊断测试缺乏共识，以及全球治疗管理的差异，导致了该疾病预后存在不确定性。本综述旨在更新眼结核的最新进展。特别是，眼结核协作研究（COTS）小组最近标准化了一种用于定义临床表型的命名系统，并提出了针对眼结核不同临床表型管理的共识指南和算法方法。实验研究的最新进展以及分子诊断和成像技术的创新，为该疾病的发病机制和自然史提供了新的认识。
