Brown K N, Hills L A
Bull World Health Organ. 1979;57 Suppl 1(Suppl):135-8.
The possibility that autoimmune responses to modified red cell antigens might be involved in protective immunity to malaria was investigated in Plasmodium berghei infection of August rats. Animals rendered anaemic by phenylhydrazine treatment at the time of immunization showed significantly greater protection than rats given antigen alone, or phenylhydrazine alone. Adoptive transfer experiments indicated that this enhanced response could be transferred with spleen cells.
在对八月龄大鼠进行伯氏疟原虫感染实验中，研究了针对修饰红细胞抗原的自身免疫反应可能参与疟疾保护性免疫的可能性。在免疫时经苯肼处理而致贫血的动物，其受到的保护作用明显大于单独给予抗原或单独给予苯肼的大鼠。过继转移实验表明，这种增强的反应可通过脾细胞进行转移。
