大鼠中T细胞与对伯氏疟原虫的保护性免疫
T cells and protective immunity to Plasmodium berghei in rats.
作者信息
Brown K N, Jarra W, Hills L A
出版信息
Infect Immun. 1976 Oct;14(4):858-71. doi: 10.1128/iai.14.4.858-871.1976.
Abstract
Experiments were carried out in which unfractionated spleen cells, and T lymphocyte subpopulations characterized by certain experimental criteria, were isolated at various times from rats infected with Plasmodium berghei. By adoptive transfer it was shown that unfractionated spleen cells, and T cells alone, could transfer protection to syngenic recipients as early as 11 days after infection of the cell donors. The protection conferred by T cells increased with the duration of the infection in the donors, at least up to 100 days. The additional presence of B cells in transferred lymphocyte populations enhanced their protective capacity over that shown by T cells alone. The role of T cells in protective immunity to malaria is discussed.
摘要
进行了如下实验
从感染伯氏疟原虫的大鼠中，在不同时间分离出未分级的脾细胞以及根据特定实验标准鉴定的T淋巴细胞亚群。通过过继转移实验表明，未分级的脾细胞以及单独的T细胞，在细胞供体感染后最早11天就能将保护性免疫传递给同基因受体。T细胞提供的保护作用随着供体感染时间的延长而增强，至少在100天内如此。转移的淋巴细胞群体中额外存在的B细胞增强了其保护能力，超过了单独T细胞所显示的保护能力。本文讨论了T细胞在疟疾保护性免疫中的作用。
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