验证一种新型的超声多普勒监测设备（早期预警）用于检测微血管循环变化。

Validation of a novel ultrasound Doppler monitoring device (earlybird) for detection of microvascular circulatory changes.

机构信息

Department of Surgery, Sørlandet Sykehus Kristiansand, Kristiansand, Norway.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

出版信息

Clin Hemorheol Microcirc. 2020;74(4):429-440. doi: 10.3233/CH-190707.

DOI:10.3233/CH-190707

PMID:31743988

Abstract

OBJECTIVE

In this proof-of-concept study we aim to validate a novel ultrasound Doppler monitoring device for evaluating microcirculation (earlybird) against LDF and pulsed Doppler.

METHODS

In ten healthy subjects, we measured microcirculatory function at rest and during different autonomic tests (forced respiration, isometric exercise, Valsalva maneuver and cold pressor). Earlybird, LDF and pulsed Doppler were recorded simultaneously. We performed a ZNCC to determine correlation.

RESULTS

The curves for earlybird and LDF or pulsed Doppler correlates visually well. Overall median ZNCC 0.87 (interquartile range 0.77 -0.91) between the LDF and earlybird measurements, and 0.90 (0.82 - 0.95) for pulsed Doppler and earlybird. Median ZNCC for baseline and each provocation test for earlybird against LDF and pulsed Doppler were calculated; baseline: LDF 0.87 (0.73 - 0.97) pulsed Doppler 0.91 (0.81 - 0.94), forced respiration: LDF 0.87 (0.28 - 0.90) pulsed Doppler 0.90 (0.85 - 0.96), isometric exercise: LDF 0.82 (0.59 - 0.90) pulsed Doppler 0.87 (0.68 - 0.94), Valsalva maneuver: LDF 0.88 (0.82 - 0.91) pulsed Doppler 0.94 (0.92 - 0.97) and cold pressor: LDF 0.90 (0.85 - 0.95) pulsed Doppler 0.89 (0.65 - 0.94).

CONCLUSION

Earlybird records vasoconstrictions in healthy subjects as well as LDF and pulsed Doppler.

摘要

目的

在这项概念验证研究中，我们旨在验证一种新的超声多普勒监测设备（早期鸟类）用于评估微循环，与 LDF 和脉冲多普勒相比。

方法

在 10 名健康受试者中，我们在休息时和进行不同自主测试（强制呼吸、等长运动、瓦尔萨尔瓦动作和冷加压）期间测量微循环功能。同时记录早期鸟类、LDF 和脉冲多普勒。我们进行了 ZNCC 以确定相关性。

结果

早期鸟类和 LDF 或脉冲多普勒的曲线在视觉上相关性良好。LDF 和早期鸟类测量之间的总体中位数 ZNCC 为 0.87（四分位距 0.77-0.91），而脉冲多普勒和早期鸟类之间的中位数 ZNCC 为 0.90（0.82-0.95）。计算了早期鸟类与 LDF 和脉冲多普勒相比的基线和每个激发试验的中位数 ZNCC；基线：LDF 0.87（0.73-0.97）脉冲多普勒 0.91（0.81-0.94），强制呼吸：LDF 0.87（0.28-0.90）脉冲多普勒 0.90（0.85-0.96），等长运动：LDF 0.82（0.59-0.90）脉冲多普勒 0.87（0.68-0.94），瓦尔萨尔瓦动作：LDF 0.88（0.82-0.91）脉冲多普勒 0.94（0.92-0.97）和冷加压：LDF 0.90（0.85-0.95）脉冲多普勒 0.89（0.65-0.94）。